{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:09:28Z","timestamp":1790777368427,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,6,3]],"date-time":"2005-06-03T00:00:00Z","timestamp":1117756800000},"content-version":"vor","delay-in-days":4644,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1992,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acute teratogenic exposure of C57Bl\/6J mouse embryos to ethanol in vivo results, within 12 hours of initial insult, in excessive cell death in selected cell populations. The patterns of excessive cell death observed following exposure of gestational day 8 embryos (late presomite\u2014approximately 5 somite pair stages) vary somewhat temporospatially, but primarily involve the cell populations at the rim of the anterior neural plate. The cell death patterns appear to be pathogenically correlated with subsequently observed malformations including exencephaly (anencephaly), arhinencephaly, pituitary dysplasia, bilateral or unilateral cleft lip, maxillary hypoplasia, and median facial deficiencies and clefts. The association of these brain and facial malformations in this model, and perhaps in humans, may be accounted for by early insult to the selected cell populations identified in the current investigation. \u00a9 1992 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.1320440210","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T16:21:30Z","timestamp":1118506890000},"page":"168-176","source":"Crossref","is-referenced-by-count":169,"title":["Experimental fetal alcohol syndrome: Proposed pathogenic basis for a variety of associated facial and brain anomalies"],"prefix":"10.1002","volume":"44","author":[{"given":"Lori E.","family":"Kotch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen K.","family":"Sulik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-2669-4"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420260305"},{"key":"e_1_2_1_4_1","first-page":"328","article-title":"Neural tube defects and fetal alcohol syndrome","volume":"94","author":"Clarren SK","year":"1979","journal-title":"J Pediatr"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)80072-9"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.103.Supplement.101"},{"key":"e_1_2_1_7_1","unstructured":"DeMeyerW(1975):Median facial malformations and their implications for brain malformations. New York:"},{"issue":"7","key":"e_1_2_1_7_2","first-page":"155","author":"National Foundation\u2014March of Dimes","journal-title":"BD:OAS"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01066065"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(82)80129-7"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420310212"},{"key":"e_1_2_1_11_1","first-page":"155","volume-title":"Syndromes of the Head and Neck","author":"Gorlin RJ","year":"1976"},{"key":"e_1_2_1_12_1","first-page":"753","article-title":"Cell death and the development of limb form and skeletal pattern in normal and wingless (ws) chick embryos","volume":"30","author":"Hinchliffe JR","year":"1973","journal-title":"J Embryol Exp Morphol"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/S0002-9378(16)33334-8","article-title":"Teratogenic effects of ethyl alcohol administered to pregnant mice","volume":"124","author":"Kronick JB","year":"1975","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1988.03720040050026"},{"key":"e_1_2_1_15_1","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1538\/expanim1978.34.3_295","article-title":"Teratogenic potentiality of single dose of thalidomide in JW\u2010NIBS rabbits","volume":"34","author":"Matsubara Y","year":"1985","journal-title":"Exp Anim"},{"key":"e_1_2_1_16_1","first-page":"105","article-title":"Neural crest formation in the head of the mouse embryo as observed using a new histological technique","volume":"64","author":"Nichols DH","year":"1981","journal-title":"J Embryol Exp Morphol"},{"key":"e_1_2_1_17_1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1242\/dev.103.Supplement.121","article-title":"Interactions of fates of avian craniofacial mesenchyme","volume":"103","author":"Noden DM","year":"1988","journal-title":"Development"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00523284"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0376-8716(85)90046-8"},{"key":"e_1_2_1_20_1","first-page":"315","article-title":"The effect of ethanol upon early development in mice and rats. II. In vitro effect upon early post\u2010implantation rat embryos","volume":"26","author":"Sandor S","year":"1980","journal-title":"Rev Roum Morphol Embryol Physiol"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420050115"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00519046"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.109.2.243"},{"key":"e_1_2_1_24_1","unstructured":"ShprintzenRJ Siegel\u2010SadewitzVL AmatoJ GoldbergRB(1985):Retrospective diagnoses of previously missed syndromic disorders among 1000 patients with cleft lip cleft palate or both. New York:"},{"issue":"2","key":"e_1_2_1_24_2","first-page":"85","author":"National Foundation\u2014March of Dimes","journal-title":"BD:OAS"},{"key":"e_1_2_1_25_1","first-page":"79","volume-title":"Holoprosencephaly: An Overview and Atlas of Cases","author":"Siebert JR","year":"1990"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00309754"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6795717"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0736-5748(84)90014-5"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320250614"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.103.Supplement.213"},{"key":"e_1_2_1_31_1","first-page":"27","volume-title":"Craniofacial Malformations","author":"Vermeij\u2010Keers C","year":"1990"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420290313"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420270211"},{"key":"e_1_2_1_34_1","first-page":"227","article-title":"Teratogenesis after acute alcohol exposure in inbred and outbred mice","volume":"2","author":"Webster WS","year":"1980","journal-title":"Neurobehav Toxicol"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/1520-6866(1990)3:5<421::AID-TCM1770030504>3.0.CO;2-V"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420350310"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320440210","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320440210","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T13:57:29Z","timestamp":1698069449000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320440210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,9,15]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1992,9,15]]}},"alternative-id":["10.1002\/ajmg.1320440210"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320440210","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,9,15]]}}}