{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T19:34:47Z","timestamp":1760729687288},"reference-count":8,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,6,7]],"date-time":"2005-06-07T00:00:00Z","timestamp":1118102400000},"content-version":"vor","delay-in-days":4601,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1992,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Previous studies have found an association between elevated second trimester maternal serum \u03b1\u2010fetoprotein (MS\u2010AFP), in the absence of fetal anomalies, and adverse pregnancy outcome. We studied the association between elevated second trimester maternal serum \u03b2\u2010HCG, now also routinely measured by prenatal screening programs, and adverse pregnancy outcome by reviewing retrospectively the pregnancy outcomes among women with markedly elevated midtrimester \u03b2\u2010HCG in our prenatal screening program. Seven (0.23%) of 3,000 consecutively screened women had a serum \u03b2\u2010HCG above 5 MOM. Four (57%) of these 7 women had an adverse pregnancy outcome including severe preeclampsia (<jats:italic>n<\/jats:italic> = 2), abruptio placentae (<jats:italic>n<\/jats:italic> = 1), or preterm labor (<jats:italic>n<\/jats:italic> = 1). A concurrently elevated MS\u2010AFP was found in only one of these 4 patients. Elevated midtrimester maternal serum \u03b2\u2010HCG may be an independent risk factor for subsequent adverse pregnancy outcomes.<\/jats:p>","DOI":"10.1002\/ajmg.1320440420","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T16:28:56Z","timestamp":1118507336000},"page":"485-486","source":"Crossref","is-referenced-by-count":37,"title":["Elevated second trimester maternal serum \u03b2\u2010HCG concentrations and subsequent adverse pregnancy outcome"],"prefix":"10.1002","volume":"44","author":[{"given":"Claudia P.","family":"Gravett","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John G.","family":"Buckmaster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter T.","family":"Watson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael G.","family":"Gravett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199111143252002"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198908103210604"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970070904"},{"key":"e_1_2_1_5_1","first-page":"709","article-title":"Outcome of pregnancy in patients with unexplained elevated or low levels of maternal serum alpha\u2010fetoprotein","volume":"72","author":"Burton BK","year":"1988","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_6_1","first-page":"465","article-title":"Significance of raised maternal serum alpha\u2010fetoprotein in singleton pregnancies with normally formed fetuses","volume":"65","author":"Hamilton MPR","year":"1985","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(87)90133-5"},{"issue":"1","key":"e_1_2_1_8_1","first-page":"55","article-title":"Preterm birth: A puzzle worth solving","volume":"76","author":"Morrison JC","year":"1990","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198908103210603"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320440420","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320440420","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T13:57:33Z","timestamp":1698069453000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320440420"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,11]]},"references-count":8,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1992,11]]}},"alternative-id":["10.1002\/ajmg.1320440420"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320440420","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,11]]}}}