{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T11:49:27Z","timestamp":1711540167230},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,6,7]],"date-time":"2005-06-07T00:00:00Z","timestamp":1118102400000},"content-version":"vor","delay-in-days":4587,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1992,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Probable Alzheimer disease (AD) is described in 79\u2010year\u2010old male twins with monozygosity confirmed by DNA examination. The first twin to be affected began to show signs of intellectual deterioration at age 70. In the other, onset was at age 72. Four of their living sibs (current age range = 75\u201392) are also suspected to have AD. The possible roles of genetic and environmental factors in the development of AD in this sibship are discussed. \u00a9 1992 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.1320440512","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T16:29:22Z","timestamp":1118507362000},"page":"591-597","source":"Crossref","is-referenced-by-count":8,"title":["Monozygotic twins concordant for late\u2010onset probable alzheimer disease with suspected alzheimer disease in four sibs"],"prefix":"10.1002","volume":"44","author":[{"given":"H.","family":"Karlinsky","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M.","family":"Berg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Lennox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. N.","family":"Ray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"St. George\u2010Hyslop","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. A.","family":"Farrer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. E.","family":"Percy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. F.","family":"Andrews","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. A.","family":"Atack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320180420"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/353844a0"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1981.00510050066011"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.39.11.1474"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.18.1.72"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(86)90071-0"},{"key":"e_1_2_1_8_1","first-page":"417","article-title":"Alzheimer's disease in identical twin brothers: investigations of their family history and of clinical development of the disease","volume":"86","author":"Doi A","year":"1984","journal-title":"Seishin Shinkeigaku Zasshi"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1985.tb02861.x"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1989.03430180093036"},{"key":"e_1_2_1_11_1","first-page":"1026","article-title":"Segregation analysis reveals evidence of a major gene for Alzheimer disease","volume":"48","author":"Farrer AL","year":"1991","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410230104"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/349704a0"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)91725-X"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)93011-W"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320400415"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.35.5.707"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1987.tb02906.x"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1986.tb04304.x"},{"key":"e_1_2_1_21_1","doi-asserted-by":"crossref","unstructured":"KarlinskyH VaulaG HainesJL RidgleyJ BergeronC MortillaM TuplerRG PercyME RobitailleY NoldyNE YipTCK TanziRE GusellaJF BeckerR BergJM McLachlanDR Crapper St. George\u2010HyslopPH(1992): Molecular and prospective phenotypic characterization of a pedigree with familial Alzheimer's disease and a missense mutation in Codon 717 of the B\u2010amyloid precursor protein gene.Neurology(in press).","DOI":"10.1212\/WNL.42.8.1445"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.46.5.421"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1991.00530140052017"},{"key":"e_1_2_1_24_1","first-page":"816","article-title":"A unified model for complex segregation analysis","volume":"35","author":"Lalouel JM","year":"1983","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.50.3.333"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-8503-5_6"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"e_1_2_1_28_1","first-page":"93","volume-title":"Alzheimer's Disease Research: Ethical and Legal Issues","author":"McLachlan DRC","year":"1991"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1925564"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)91612-X"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.37.3.359"},{"key":"e_1_2_1_32_1","first-page":"1034","article-title":"Linkage studies in familial Alzheimer disease: Evidence for chromosome 19 linkage","volume":"48","author":"Pericak\u2010Vance MA","year":"1991","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.149.4.509"},{"key":"e_1_2_1_34_1","first-page":"61","article-title":"Identical twins with probable Alzheimer's disease: Behaviour, anatomY, and physiology","volume":"1","author":"Resnick SM","year":"1988","journal-title":"Neuropsychiat Neuropsychol Behav Neurol"},{"key":"e_1_2_1_35_1","volume-title":"Current Communications in Molecular Biology of Alzheimer's Disease","author":"Roses AD","year":"1988"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3420406"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/82.15.1272"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700034103"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/347194a0"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(89)90082-1"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2880399"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1159\/000212515"},{"key":"e_1_2_1_43_1","first-page":"A205","article-title":"The familial Alzheimer's disease gene is located close to the centromere of chromosome 21","volume":"43","author":"Van Broeckhoven C","year":"1988","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2880398"},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.930050303"},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320290227"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320440512","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320440512","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T11:18:06Z","timestamp":1698059886000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320440512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,11,15]]},"references-count":45,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1992,11,15]]}},"alternative-id":["10.1002\/ajmg.1320440512"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320440512","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,11,15]]}}}