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The interactious can be disturbed or modulated by an abnormal distribution on the collagen fibril surface of electrically charged or hydrophobic groups, or by an increased presence of sugar moieties linked to hydroxylysyl residues due to chain post\u2010translational overmodifications (lysyl overhydroxylation and hydroxylysyl over\u2010glycosylation) of the portion of the triple helical domain of abnormal type I collagen molecules N\u2010terminal with respect to the defect localization.<\/jats:p>","DOI":"10.1002\/ajmg.1320450219","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T16:39:13Z","timestamp":1118507953000},"page":"252-256","source":"Crossref","is-referenced-by-count":33,"title":["Possible role of overglycosylation in the type I collagen triple helical domain in the molecular pathogenesis of osteogenesis imperfecta"],"prefix":"10.1002","volume":"45","author":[{"given":"Ruggero","family":"Tenni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizia","family":"Valli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Cetta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2400699"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"7021","DOI":"10.1016\/S0021-9258(18)48196-3","article-title":"Lethal perinatal osteogenesis imperfecta due to the substitution of arginine for glycine at residue 391 of the \u03b1 1(I) chain of type I collagen","volume":"262","author":"Bateman JF","year":"1987","journal-title":"J Biol Chem"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-516304-0.50009-X"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0169-6009(89)90044-5"},{"key":"e_1_2_1_6_1","first-page":"2805","volume-title":"The Metabolic Basis of Inherited Disease","author":"Byers PH","year":"1989"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/03008207709152612"},{"key":"e_1_2_1_8_1","first-page":"337","article-title":"Glycosaminoglycan alterations in osteogenesis imperfecta","volume":"29","author":"Cetta G","year":"1980","journal-title":"Ital J Biochem"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/03008208309004847"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-2831-5_1"},{"key":"e_1_2_1_11_1","first-page":"403","article-title":"Proteoglycan modifications in cultured osteogenesis imperfecta skin fibroblasts","volume":"33","author":"De Luca G","year":"1984","journal-title":"Ital J Biochem"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-1508-8_1"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.53.070184.003441"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(83)80347-7"},{"key":"e_1_2_1_15_1","first-page":"6511","article-title":"Maturation of collagenous tissue","volume":"255","author":"Fukae M","year":"1980","journal-title":"J Biol Chem"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(80)90182-5"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(89)90335-5"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(89)90044-5"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"15696","DOI":"10.1016\/S0021-9258(18)47783-6","article-title":"Assembly of collagen fibrils de novo by cleavage of the type I pC\u2010collagen with procollagen C\u2010proteinase. 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