{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:15:49Z","timestamp":1790223349457,"version":"4.1.0"},"reference-count":5,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,6,7]],"date-time":"2005-06-07T00:00:00Z","timestamp":1118102400000},"content-version":"vor","delay-in-days":4481,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1993,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We describe a family with at least seven living persons who are affected by an hitherto undescribed autosomal\u2010dominant syndrome with variable expression, bearing close resemblance to the EEC syndrome and related disorders. The main manifestations are hypodontia and\/or early loss of permanent teeth, ectrodactyly, obstruction of lacrimal ducts, onychodysplasia, and excessive freckling. We propose the acronym ADULT (<jats:italic>a<\/jats:italic>cro\u2010<jats:italic>d<\/jats:italic>er\u2010mato\u2010<jats:italic>u<\/jats:italic>ngual\u2010<jats:italic>l<\/jats:italic>acrimal\u2010<jats:italic>t<\/jats:italic>ooth)\u2010syndrome for this condition. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.1320450525","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T16:48:59Z","timestamp":1118508539000},"page":"642-648","source":"Crossref","is-referenced-by-count":61,"title":["ADULT\u2010syndrome: An autosomal\u2010dominant disorder with pigment anomalies, ectrodactyly, nail dysplasia, and hypodontia"],"prefix":"10.1002","volume":"45","author":[{"given":"Peter","family":"Propping","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Zerres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6,7]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"107","article-title":"Association dysplasie ectodermique et syndactylie","volume":"118","author":"Boudghene\u2010Stambouli O","year":"1991","journal-title":"Ann Dermatol Venereol"},{"key":"e_1_2_1_3_1","first-page":"370","article-title":"A newly recognised genetic syndrome of tetramelic deficiencies, ectodermal dysplasia, deformed ears and other abnormalities","volume":"22","author":"Freire\u2010Maia N","year":"1970","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1542\/peds.30.5.797","article-title":"Familial ectodermal dysplasia with sensorineural deafness and other anomalies","volume":"30","author":"Robinson GC","year":"1962","journal-title":"Pediatrics"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320370112"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1001\/archderm.1986.01660210097027","article-title":"A previously undescribed ectodermal dysplasia of the tricho\u2010odonto\u2010onychial subgroup in a family","volume":"122","author":"Tsakalakos N","year":"1986","journal-title":"Arch Dermatol"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320450525","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320450525","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T08:21:12Z","timestamp":1698308472000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320450525"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,3]]},"references-count":5,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1993,3]]}},"alternative-id":["10.1002\/ajmg.1320450525"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320450525","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,3]]}}}