{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T03:25:08Z","timestamp":1700277908880},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,6,7]],"date-time":"2005-06-07T00:00:00Z","timestamp":1118102400000},"content-version":"vor","delay-in-days":4436,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1993,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report on an 18\u2010week fetus with cyclopia, alobar holoprosencephaly, complex congenital heart defect, anal atresia, oligosyndactyly, cystic hygroma, and skeletal abnormalities with trisomy 4. Structural anomalies were detected on routine ultrasound of the pregnancy of a 17\u2010year\u2010old G3 P1 TAB1 woman with sickle cell trait. Trisomy 4 conceptuses usually miscary in the first trimester. We are aware of no other reports of a fetus with trisomy 4 and cyclopia. Causal association of chromosome abnormalities and holoprosencephaly sequence amay be more apparent in embryos and early fetuses than term fetuses because of poor viability of affected conceptuses. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.1320460219","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T16:50:25Z","timestamp":1118508625000},"page":"193-197","source":"Crossref","is-referenced-by-count":14,"title":["Trisomy 4 in a fetus with cyclopia and other anomalies"],"prefix":"10.1002","volume":"46","author":[{"given":"Margot I.","family":"Van Allen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Ritchie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ants","family":"Toi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Fong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Winsor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420120103"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420140103"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420320218"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(67)90488-7"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420400304"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320340232"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320340229"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1542\/peds.34.2.256","article-title":"The face predict the brain: Diagnostic significance of median facial anomalies for holoprosencephaly (arhinencephaly)","volume":"34","author":"DeMyer W","year":"1964","journal-title":"Pediatrics"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320140104"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.151.2.6709918"},{"key":"e_1_2_1_12_1","unstructured":"GurrieriF KraussCM SchindlerD SchinzelA KunzeJ WegnerR\u2010D FrynsJ\u2010P SchwartzS PettanatiMJ KniselyAS PunnettHH TsuiL\u2010C MuenkeM(1992):Clinical cytogenetic and molecular genetic studies in patients with holoprosencephaly (HPE) and terminal deletions of chromosome 7q. 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