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This type is relatively rarely associated with nonlimb defects, a single limb is affected in two\u2010thirds of cases, nearly all other cases had femur\u2010fibula\u2010ulna (FFU) dysostosis. Upper and lower limbs, right and left sides, are equally affected, however, there is an obvious male excess (71%). Case\u2010control analysis indicated a lower birth weight due to intrauterine growth retardation, higher birth order, lower socioeconomic status of parents, and a more frequent reported subfertility. The family study identified one familial cluster (one siboccurrence) among 331 first\u2010degree relatives. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.1320460416","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T16:28:22Z","timestamp":1118507302000},"page":"427-433","source":"Crossref","is-referenced-by-count":8,"title":["Causal study of isolated ulnar\u2010fibular deficiency in Hungary, 1975\u20131984"],"prefix":"10.1002","volume":"46","author":[{"given":"Andrew E.","family":"Czeizel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rta","family":"Vit\u00e9z","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imre","family":"Kodaj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Widukind","family":"Lenz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420030307"},{"key":"e_1_2_1_3_1","volume-title":"Congenital Deformities of the Upper Extremities","author":"Birch\u2010Jensen A","year":"1949"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420310314"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1093\/oxfordjournals.aje.a112623","article-title":"Estimation of multiple relative risk functions in matched case control studies","volume":"108","author":"Breslow NE","year":"1978","journal-title":"Am J Epidemiol"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.27.6.353"},{"key":"e_1_2_1_7_1","first-page":"219","article-title":"The activities of the Hungarian Centre for Congenital Anomaly Control","volume":"41","author":"Czeizel A","year":"1988","journal-title":"WHO Stat Rep Quart"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00285025"},{"key":"e_1_2_1_9_1","first-page":"229","article-title":"Birth prevalence of different congenital limb deficiency types in a population\u2010based revised Hungarian material, 1975\u20131984","volume":"39","author":"Czeizel A","year":"1991","journal-title":"Acta Morphol Hung"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/352429a0"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/342767a0"},{"key":"e_1_2_1_12_1","unstructured":"EvansJA Vit\u00e9zM CzeizelA(1993):Congenital abnormalities associated with limb reduction deficiencies: A population\u2010based Hungarian study. 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