{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:01:25Z","timestamp":1787162485396,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,6,7]],"date-time":"2005-06-07T00:00:00Z","timestamp":1118102400000},"content-version":"vor","delay-in-days":4375,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1993,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Data from 4,300 consecutive cases following prenatal diagnosis by transcervical (TC) CVS (n = (1,570) and transabdominal (TA) CVS (n = 2,370) were evaluated. In the follow\u2010up study only infants examined by a physician were included. Gestational age varied between 8.5 and 11.6 weeks (mean 10.3 weeks) for TC\u2010CVS and between 9.3 and 20 weeks (mean 12.3 weeks) for TA\u2010CVS 98% of TC\u2010CVS was performed at 9\u201310 weeks, 80.7% of TA\u2010CVS procedures were carried out at 12\u201315 weeks. Selective termination took place in 97 cases of TC\u2010CVS (6.1%) and in 72 cases of TA\u2010CVS (2.6%). Another 8 Women had a termination for psychosocial reasons, resulting in 4,123 (1,469 TC, 2,645 TA) continuing pregnancies. The overall fetal loss rare &lt;28 weeks was 5.4% (n = 80) for TC\u2010CVS and 2.6% (n = 70) for TA\u2010CVS. The overall incidence of congenital abnormalities after birth was 0.9%. Two terminal transversal limb defects were detected in the TC\u2010CVS group (0.14%) against one (0.04%) in the TA\u2010CVS group. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.1320460503","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T12:59:31Z","timestamp":1118494771000},"page":"483-485","source":"Crossref","is-referenced-by-count":20,"title":["Terminal transverse limb defects and early chorionic villus sampling: Evaluation of 4,300 cases with completed follow\u2010up"],"prefix":"10.1002","volume":"46","author":[{"given":"Milena G. 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