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On autopsy he had fusion of the anterior cerebral hemispheres, accompanied by agenesis of olfactory bulbs and tracts, closely resembling those found in semi\u2010lobar holoprosencephaly. In addition, heterotopic Purkinje cell cluster in the cerebellar white matter, absence of pigmentation within the brainstem pigmented neurons, and severe hypomyelination in the whole brain were noted.<\/jats:p><jats:p>The patient may represent the most severe manifestation of ring chromosome 7, and this is the first detailed neuropathological report on this subject. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.1320460606","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T16:59:55Z","timestamp":1118509195000},"page":"632-635","source":"Crossref","is-referenced-by-count":14,"title":["Case of ring chromosome 7: The first report of neuropathological 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