{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:27:39Z","timestamp":1786976859605,"version":"build-2736575974"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,6,7]],"date-time":"2005-06-07T00:00:00Z","timestamp":1118102400000},"content-version":"vor","delay-in-days":4359,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1993,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Acalvaria is a rare malformation usually regarded as a postneurulation defect. It consists of absense of the calvarial bones, dura mater and associated muscles in the presence of a normal skull base and normal facial bones. The condition is frequenctly confused by prenatal ultrasonography with anencephaly or an encephalocele. Whereas the cerebral hemispheres are absent in anencephaly, the cranial contents in acalvaria are generally complete, though some neuropathological abnormality is often present. The presumed pathogenesis of acalvaria is faulty migration of the membranous neurocranium with normal placement of the embryonic ectoderm, resulting in absence of the calvaria but an intact layer of skin over the brain parenchyma. We describe 2 cases of acalvaria, one misdiagnosed ultrasonographically as an occipital encephalocele prenatally. The brain in one fetus demonstrated semilobar holoprosencephaly and micropolygyria, but in the other, was structurally and histologically normal with the exception of hydrocephalus. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.1320460620","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T12:59:55Z","timestamp":1118494795000},"page":"694-699","source":"Crossref","is-referenced-by-count":30,"title":["Acalvaria: A unique congenital anomaly"],"prefix":"10.1002","volume":"46","author":[{"given":"Cheryl P.","family":"Harris","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeannette J.","family":"Townsend","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Carey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420440503"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.1870190409"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.1870190608"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420170114"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-198503000-00024"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.1330620106"},{"key":"e_1_2_1_8_1","first-page":"1","article-title":"Acrania: Review of 13 cases","volume":"1","author":"Kwon TH","year":"1991","journal-title":"The Fetus"},{"key":"e_1_2_1_9_1","first-page":"215","volume-title":"Normal and Abnormal Development of the Human Nervous System","author":"Lemire RJ","year":"1975"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1988.03720040050026"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.139.1.181"},{"key":"e_1_2_1_12_1","first-page":"421","article-title":"Aplasia cutis congenita","volume":"130","author":"Martin J","year":"1984","journal-title":"Can Med Assoc J"},{"key":"e_1_2_1_13_1","first-page":"206","volume-title":"Textbook of Fetal and Perinatal Pathology","author":"Rushton DI","year":"1991"},{"key":"e_1_2_1_14_1","first-page":"319","article-title":"Acalvaria, Holoprosencephaly, and facial dysmorphism syndrome","volume":"2","author":"Sperber GH","year":"1986","journal-title":"Craniof Genet Dev Biol (suppl)"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.1987.6.12.715"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320460620","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320460620","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T00:56:56Z","timestamp":1698281816000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320460620"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,7]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1993,7]]}},"alternative-id":["10.1002\/ajmg.1320460620"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320460620","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,7]]}}}