{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T21:11:11Z","timestamp":1773868271921,"version":"3.50.1"},"reference-count":9,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2005,6,3]],"date-time":"2005-06-03T00:00:00Z","timestamp":1117756800000},"content-version":"vor","delay-in-days":4218,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1993,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Gastroesophageal reflux is a common occurrence in infancy. The most severe complications of reflux include torticollis, opisthotonus, and paroxysmal dystonic posture (known as rhe Sandifer complex). We examined 17 patients now ranging in age from 9 months to 19 years (mean age 11 years) with the Brachmann\u2010de Lange syndrome for evidence of gastroesophageal reflux and found that 13 had not only reflux, but also posturing and behavior consistent with the Sandifer complex. We propose that early recognition of gastroesophageal reflux in these patients may prevent the full picture of the Sandifer complex and allow for medical treatment rather than surgical intervention. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.1320470719","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T17:12:04Z","timestamp":1118509924000},"page":"1026-1028","source":"Crossref","is-referenced-by-count":23,"title":["Occurrence of the Sandifer complex in the Brachmann\u2010de Lange syndrome"],"prefix":"10.1002","volume":"47","author":[{"given":"Annemarie","family":"Sommer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,3]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"224","article-title":"Ein Fall von symmetrischer Monodaktylie durch Ulnadefekt, mit symmetrischer Flughautbildung in den Ellenbeugen, sowie anderen Abnormitaten (Zwerghaftigkeit, Halsrippen, Behaarung)","volume":"84","author":"Brachmann W","year":"1916","journal-title":"Jb Kiderheilk"},{"key":"e_1_2_1_3_1","first-page":"486","volume-title":"Birth Defects Encyclopedia","author":"Buyse ML","year":"1990"},{"key":"e_1_2_1_4_1","first-page":"51","article-title":"Torticolis de \u00ccenfant: ne pas oublier le syndrome de Sandifer","volume":"37","author":"Dabadie A","year":"1990","journal-title":"Annales de Pediatrie"},{"key":"e_1_2_1_5_1","first-page":"713","article-title":"Sur un type nouveau de degeneration (typus Amstelodamensis)","volume":"36","author":"de Lange C","year":"1993","journal-title":"Archives de Medecine des Enfants"},{"key":"e_1_2_1_6_1","first-page":"1048","article-title":"Hiatus hernia with contortions of the neck","volume":"1","author":"Kinsbourne M","year":"1964","journal-title":"Lancet"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1989.tb11150.x"},{"key":"e_1_2_1_8_1","first-page":"857","article-title":"Dystonie als Komplikation bei Gastroesophagealem Reflux: Sandifer Syndrom","volume":"135","author":"Sacher M","year":"1987","journal-title":"Monatsschrift Kinderheilkunde Dez"},{"key":"e_1_2_1_9_1","first-page":"190","article-title":"Torsion spasms and abnormal postures in children with hiatus hernia, Sandifer's syndrome","volume":"2","author":"Sutcliffe J","year":"1969","journal-title":"Pro Pediatr Radiol"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320280206"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320470719","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320470719","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T06:19:28Z","timestamp":1698214768000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320470719"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,11,15]]},"references-count":9,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1993,11,15]]}},"alternative-id":["10.1002\/ajmg.1320470719"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320470719","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,11,15]]}}}