{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:07:52Z","timestamp":1792062472222,"version":"4.4.0"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,6,7]],"date-time":"2005-06-07T00:00:00Z","timestamp":1118102400000},"content-version":"vor","delay-in-days":4253,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1993,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sixty\u2010seven adolescents participated in this protocol, including 42 with sex chromosome abnormalities and 25 controls. Results from a battery of neuropsychological tests indicated karyotype specific patterns of neuropsychological impairment: (1) 47,XXY boys had unimpaired intelligence but reduced abilities in verbal fluency and reading; (2) 47,XXX girls experienced reduced general intelligence accompanied by impaired scores on individual tests of attention, concept formation, spatial thinking, verbal fluency, and academic skills, while retention of memorized information was a relative strength; (3) among the 45,X girls average intelligence level was also reduced along with scores on tests of attention, concept formation, verbal fluency, spatial thinking, and academic skills, and an atypical pattern of hand dominance was identified; (4) test scores in the group of mosaic females did not differ from those of controls. Test scores and patterns of personal adaptation were quite variable in all groups; while eight nonmosaic propositi required intensive special education assistance in their public schooling, eight others have attended college.\u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.1320480312","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T00:59:53Z","timestamp":1118537993000},"page":"169-173","source":"Crossref","is-referenced-by-count":111,"title":["Neuropsychological impairment in 42 adolescents with sex chromosome abnormalities"],"prefix":"10.1002","volume":"48","author":[{"given":"Bruce G.","family":"Bender","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary G.","family":"Linden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1542\/peds.71.2.262","article-title":"Speech and language development in 41 children with sex chromosome anomalies","volume":"71","author":"Bender B","year":"1983","journal-title":"Pediatrics"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-198707000-00006"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198906000-00004"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00354965"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1542\/peds.73.2.175","article-title":"Cognitive development of uselected girls with X and partial X monosomy","volume":"73","author":"Bender B","year":"1984","journal-title":"Pediatrics"},{"key":"e_1_2_1_7_1","first-page":"175","volume-title":"Genetics and Learning Disabilities","author":"Bender B","year":"1986"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0093-934X(88)90064-8"},{"key":"e_1_2_1_9_1","volume-title":"Children and Young Adults With Sex Chromosome Aneuploidy: Follow\u2010up, Clinical, and Molecular Studies. BD:OAS 26(4)","author":"Evans JA","year":"1990"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01066000"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1542\/peds.81.6.795","article-title":"Oral and written language abilities of XYY boys: Implications for anticipatory guidance","volume":"81","author":"Graham JM","year":"1988","journal-title":"Pediatrics"},{"key":"e_1_2_1_12_1","first-page":"179","volume-title":"Genetic Aspects of Speech and Language Disorders","author":"Netley C","year":"1983"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.2307\/1129006"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320090207"},{"issue":"3","key":"e_1_2_1_15_1","first-page":"73","article-title":"Edinburgh study of growth and development of children with sex chromosome abnormalities. III","volume":"22","author":"Ratcliffe SG","year":"1986","journal-title":"BD:OAS"},{"key":"e_1_2_1_16_1","volume-title":"Prospective Studies on Children With Sex Chromosome Aneuploidy.\u201d BD:OAS 22(3)","author":"Ratcliffe SG","year":"1986"},{"issue":"4","key":"e_1_2_1_17_1","first-page":"41","article-title":"The Edinburgh study of growth and development of children with sex chromosomal abnormalities","volume":"18","author":"Ratcliffe SG","year":"1982","journal-title":"BD:OAS"},{"issue":"4","key":"e_1_2_1_18_1","first-page":"225","article-title":"Summary and profiles of children with sex chromosome anomalies","volume":"26","author":"Robinson A","year":"1990","journal-title":"BD:OAS"},{"key":"e_1_2_1_19_1","volume-title":"Sex chromosome aneuploidy: Prospective studies on children.\u201d BD:OAS 15(1)","author":"Robinson A.","year":"1979"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.148.3666.83"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1037\/0012-1649.18.1.77"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.2307\/1129888"},{"key":"e_1_2_1_23_1","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1542\/peds.84.4.678","article-title":"Gross and fine motor development in 45, X and 47, XXX females","volume":"84","author":"Salbenblatt JA","year":"1989","journal-title":"Pediatrics"},{"key":"e_1_2_1_24_1","volume-title":"Children With Sex Chromosome Aneuploidy: Follow\u2010up Studies.\u201d BD:OAS 18(4)","author":"Stewart DA","year":"1982"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320480312","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320480312","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T06:42:26Z","timestamp":1698302546000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320480312"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,10,15]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1993,10,15]]}},"alternative-id":["10.1002\/ajmg.1320480312"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320480312","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,10,15]]}}}