{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T01:18:20Z","timestamp":1768439900285,"version":"3.49.0"},"reference-count":66,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,6,7]],"date-time":"2005-06-07T00:00:00Z","timestamp":1118102400000},"content-version":"vor","delay-in-days":4175,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1994,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Limb deficiency defects (LD) occurring among 1,575,904 births in Hungary during 1975\u20131984 were reviewed. The overall birth prevalence of LD was 1 in 1,816. This paper discusses the nature and distribution of the limb and other defects in the 275 (32%) children who had structural malformations in other systems. Two main forms of classification were used: morphologic and causal.<\/jats:p><jats:p>Additional malformations were most commonly seen in infants with amelia, rudimentary limb (RL), radial\/tibial (RT), intercalary or central axis (CA) LD and rarely in those with terminal transverse (TT) or ulnar\/fibular (UF) defects. Upper limbs (81%) were involved significantly more often than lower limbs (42%) and there were more right\u2010sided defects (83% vs. 71%) due to an excess of right arm involvement especially with radial ray and split hand anomalies. Single limb involvement was relatively common withy amelia (88%), UF (82%), RT (50%), and TT defects. With other LD, multimelic involvement was more characteristic. This was usually symmetric with Ca anomalies and digital deficiencies (DD).<\/jats:p><jats:p>From a causal perspective, 17% of cases had genetic disordes, 52% had recognized associations, anomalies, sequences, environmental causes or patterns of unknown origin, and 31% had unknown patterns of malformations. The commonest entities were amnion disruption sequence (16% of cases) and VACTERL association (8%). Both of these disorders showed unusual temporal distribution.<\/jats:p><jats:p>As anticipated, patterns of malformations differed with the type of LD. Amelia and digital amputations were often seen with body wall defects, atypical anencephaly or encephalocele, and cleft lip reflecting amnion disruption. Rudimentary limb was seen with anencephaly, omphalocele, renal agenesis, aberrant genitalia, and imperforate anus, reflecting defects of blastogenesis including the cloacal exstrophy and caudal regression sequences and Schisis association. Radial\/tibial defects were associated with different patterns depending on whether the limp defects were unilateral or bilateral. Unilateral defects occurred with anomalies suggesting VACTERL association or the facio\u2010auriculo\u2010vertebral anomaly, while bilateral defects occured more often in genetic or potentially genetic disorders including VACTERL with hydrocephalus. Central axis defects showed three main patterns of association: one reflecting the ectrodacyly\u2010ectodermal dysplasia\u2010clefting syndrome; one with tongue anomalies representing a variant of oro\u2010mandibular\u2010limb (Hanhart) anomaly, and the last with hydronephrosis indicating a group of \u201cacrorenal\u201d syndromes. Strong associations with other anomalies were not seen in the grups with TT, UF, or intercalary defects. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.1320490111","type":"journal-article","created":{"date-parts":[[2005,8,8]],"date-time":"2005-08-08T21:53:47Z","timestamp":1123538027000},"page":"52-66","source":"Crossref","is-referenced-by-count":95,"title":["Congenital abnormalities associated with limb deficiency defects: A population study based on cases from the Hungarian congenital malformation registry (1975\u20131984)"],"prefix":"10.1002","volume":"49","author":[{"given":"J. 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