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Data are presented on pregnancy, delivery, survival, medical complications, immunizations, growth, cause of death, cytogenetics, and recurrence risk. Half of the trisomy 18 babies were delivered by C\u2010section. Fetal distress was a factor in half, and the only reason in a third of C\u2010section deliveries. One minute Apgar scores were significantly lower in C\u2010section and breech deliveries. There were more small for gestational age babies than in the general population, but most of the low birth weight new borns were small for gestational age, unlike the general population. Survival in this group of children was better than in other studies due to ascertainment bias. There were more girls than boys at all ages for both conditions, and the sex ratio decreased with time. Growth curves for length, weight, head circumference, and weight vs height are provided. Long\u2010term survival did not appear to be due to mosaicism. We found no adverse reactions attributable to immunizations. At age 1 year there was an average of approximately 2 operations per living child. We report the second case of successful major cardiac surgery in a trisomy 18 child. Almost 70% of deaths were attributed to cardiopulmonary arrest. The sibling recurrence risk for trisomy 18 or trisomy 13 was 0.55%. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.1320490204","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T13:13:14Z","timestamp":1118495594000},"page":"175-188","source":"Crossref","is-referenced-by-count":248,"title":["Natural history of trisomy 18 and trisomy 13: I. Growth, physical assessment, medical histories, survival, and recurrence risk"],"prefix":"10.1002","volume":"49","author":[{"given":"Bonnie J.","family":"Baty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent L.","family":"Blackburn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Carey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1974.tb02092.x"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1982.tb01848.x"},{"key":"e_1_2_1_4_1","first-page":"43","article-title":"Development in trisomy 18 and trisomy 13","volume":"49","author":"Baty B","year":"1991","journal-title":"Am J Hum Genet (Suppl)"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320490205"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(88)90165-2"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1542\/peds.50.6.908","article-title":"Parental mosaicism in trisomy 18","volume":"50","author":"Beratis NG","year":"1972","journal-title":"Pediatr"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02953676"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-3782(83)90010-5"},{"key":"e_1_2_1_10_1","first-page":"288","article-title":"Trisomy 13 syndrome: A rare case of long term survival","volume":"11","author":"Boraz RA","year":"1987","journal-title":"J Pedodont"},{"key":"e_1_2_1_11_1","first-page":"510","volume-title":"Maternal\u2010Fetal Medicine. 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