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The pattern of abnormalities identified appears to be limited to structures sharing a common embryologic origin. These features, for the most part, are shown to be non\u2010randomly associated. No clearly definable sub\u2010groups within this population are demonstrable. The pattern of abnormalities is defined to include abnormalities of the following structures as pathogenetically primary features: lumbosacral vertebrae, kidneys, ureters, uterus\/fallopian tubes, vagina, bladder, urethra, adrenals, gonads, anorectum, external genitalia, and umbilical arteries. An embryologic mechanism is proposed which explains this non\u2010random association as arising secondary to disruption of structures derived from the lower portion of the primitive intra\u2010embryonic mesoderm. The Lower Mesodermal Defects Sequence appears to be a rather common (and under\u2010recognized) cause of stillbirth and immediate neonatal death. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.1320500206","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T17:02:30Z","timestamp":1118509350000},"page":"154-172","source":"Crossref","is-referenced-by-count":50,"title":["Lower mesodermal defects: A common cause of fetal and early neonatal death"],"prefix":"10.1002","volume":"50","author":[{"given":"Richard M.","family":"Pauli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.4135\/9781412983648"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/S0022-5347(17)38523-3","article-title":"Cloacal anomalies and other urorectal septal defects in female patients: A spectrum of anatomical abnormalities","volume":"145","author":"Allen TD","year":"1991","journal-title":"J Urol"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02926571"},{"key":"e_1_2_1_5_1","first-page":"182","article-title":"Hindgut\u2010cloacal atresias as a spectrum of caudal field defects in the human fetus","volume":"7","author":"Barr M","year":"1988","journal-title":"Proc Greenwood Genet Center"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(78)90001-8"},{"key":"e_1_2_1_7_1","first-page":"67","article-title":"Fetal genitourinary tract anomalies: Evaluation, operative correction, and follow\u2010up","volume":"75","author":"Callan NA","year":"1990","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_8_1","volume-title":"The OEIS complex","author":"Carey JC","year":"1978"},{"issue":"6","key":"e_1_2_1_8_2","first-page":"253","article-title":"National Foundation\u2013March of Dimes","journal-title":"BD:OAS"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(59)90168-1"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420360104"},{"key":"e_1_2_1_11_1","first-page":"37","volume-title":"Patten's Human Embryology. 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