{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T14:06:14Z","timestamp":1773324374735,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,6,7]],"date-time":"2005-06-07T00:00:00Z","timestamp":1118102400000},"content-version":"vor","delay-in-days":3932,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1994,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Anencephaly is Suspected to cluster in the municipality of Cubat\u00e3o (Brazil), and is attributed to industrial pollution. We surveyed malformations prospectively in 10,000 births, in 3 consecutive series, corresponding to 3 maternity hospital in Cubat\u00e3o, under working definitions and norms taken from the ECLAMC (Latin American Collaborative Study of Congenital Malformations). The sample from Cubat\u00e3o had a higher proportion of black racial ancestry, and lower frequencies for stillbirths and for immediate neonatal death, than in the rest of South America.<\/jats:p><jats:p>The birth prevalence of malformations varied between the 3 hospitals in Cubat\u00e3o, due to differences in ascertainment of minor defects. A higher\u2010than\u2010expected prevalence rate in Cubat\u00e3o was observed only for postaxial polydactyly, probably due to a higher proportion of black racial ancestry, while lower\u2010than\u2010expected rates were obtained for congenital dislocation of the hip, and for babies with multiple congenital anomalies patterns, both of them attributed to underascertainment of minor defects.<\/jats:p><jats:p>These observations do not support the suspicion of an elevated birth prevalence rate for anencephaly, neural tube defects, or any other major congenital malformation in Cubat\u00e3o. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.1320520313","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T17:17:14Z","timestamp":1118510234000},"page":"319-323","source":"Crossref","is-referenced-by-count":14,"title":["Apparently normal frequency of congenital anomalies in the highly polluted town of Cubat\u00e3o, Brazil"],"prefix":"10.1002","volume":"52","author":[{"given":"Roque","family":"Monteleone\u2010Neto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo E.","family":"Castilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,7]]},"reference":[{"key":"e_1_2_1_2_1","unstructured":"BottingB SkjaervenR(1988): Attributable proportions of Down syndrome due to high maternal age 1980\u20131988. In: \u201cAnnual Report 1988. International Clearinghouse for Birth Defects Monitoring Systems.\u201d Bergen: ISSN 0743\u20135703 pp53\u201362."},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1093\/oxfordjournals.aje.a115787","article-title":"Twenty\u2010two years of cancer cluster investigations at the Centers for Disease Control","volume":"132","author":"Caldwell GG","year":"1990","journal-title":"Am J Epidemiol [Suppl]"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-75599-6_6"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320220406"},{"key":"e_1_2_1_6_1","first-page":"405","article-title":"Polydactyly: a genetic study in South America","volume":"25","author":"Castilla EE","year":"1973","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_7_1","volume-title":"Avalia\u00e7\u00e3o das emiss\u00f5es de poluentes atmosf\u00e9ricos de origem industrial na regi\u00e3o de Cubat\u00e3o. Subs\u00eddios para uma pol\u00edtica de a\u00e7\u00e3o","author":"Report CETESB","year":"1981"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115784"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1976.tb00135.x"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115776"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a113463"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(88)90004-2"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1001\/jama.1988.03720110030030","article-title":"Birth defects in the Seveso area after TCDD contamination","volume":"259","author":"Mastroiacovo P","year":"1988","journal-title":"JAMA"},{"key":"e_1_2_1_14_1","first-page":"65","volume-title":"Prevention of Physical and Mental Congenital Defects, Part B: Epidemiology, Early Detection and Therapy, and Environmental Factors","author":"Monteleone\u2010Neto R","year":"1985"},{"key":"e_1_2_1_15_1","volume-title":"Avalia\u00e7\u00e3o Preliminar da Qualidade do Ar em Cubat\u00e3o","author":"Orsini CMQ","year":"1982"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-77753-0_13"},{"key":"e_1_2_1_17_1","first-page":"1164","article-title":"A situa\u00e7\u00e3o em Cubat\u00e3o: documento s\u00edntese do grupo de trabalho sobre Cubat\u00e3o da SBPC","volume":"5","author":"Queiroz\u2010Neto JP","year":"1983","journal-title":"Ci\u011bncia e Cultura"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.2307\/3431292"},{"key":"e_1_2_1_19_1","first-page":"325","article-title":"Polui\u00e7\u00e3o marinha no Brasil: uma s\u00edntese","volume":"34","author":"Tommasi LR","year":"1982","journal-title":"Ci\u011bncia e Cultura"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115778"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320520313","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320520313","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T05:55:03Z","timestamp":1698126903000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320520313"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,9]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1994,9]]}},"alternative-id":["10.1002\/ajmg.1320520313"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320520313","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,9]]}}}