{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T11:14:02Z","timestamp":1760440442608},"reference-count":9,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,6,7]],"date-time":"2005-06-07T00:00:00Z","timestamp":1118102400000},"content-version":"vor","delay-in-days":4010,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1994,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Previous population studies of hearing loss have been limited to children with moderate to profound impairment, and have reported that heritability accounts for at least 50% of congenital or early\u2010onset cases. The present study was designed to assess genetic factors associated with late\u2010onset hearing impairment in an adult population. A brief family history and audiologic questionnaire was sent to approximately 11,200 members of the consumer organization, Self Help for the Hard of Hearing, Inc., and 4,039 questionnaires were returned. All respondents reported having at least one previous audiologic exam. Reported data were verified against audiograms when available. Regardless of the <jats:italic>reported<\/jats:italic> causes, 49% of early\u2010onset cases (\u2a7d20 years of age) had one or two parent(s) with some form of hearing loss compared with 62% in later\u2010onset cases. As expected, mean age at onset was substantially younger for cases with positive family histories than cases with negative family histories. Results from nuclear segregation analysis showed that fully recessive and dominant models failed to explain the early\u2010 or late\u2010onset hearing loss data.<\/jats:p><jats:p>In this nationwide survey, the large proportion of cases with positive family histories clearly indicates the importance of genetic factors in adult\u2010onset forms of hearing loss. Comparison with younger\u2010onset cases will permit further delineation of differences in inheritance patterns. This study should identify more homogeneous groups of adult\u2010onset families for further genetic study, and provide empiric information for use in genetic counselling. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.1320540211","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T17:50:20Z","timestamp":1118512220000},"page":"149-153","source":"Crossref","is-referenced-by-count":16,"title":["Genetic epidemiologic study of hearing loss in an adult population"],"prefix":"10.1002","volume":"54","author":[{"given":"Anne M.","family":"Sill","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa J.","family":"Stick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerie L.","family":"Prenger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan L.","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joann A.","family":"Boughman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen S.","family":"Arnos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,7]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"26","article-title":"The professionals told me what it was, but that's not enough","volume":"13","author":"Glass LE","year":"1992","journal-title":"SHHH J"},{"key":"e_1_2_1_3_1","first-page":"28","article-title":"The way less traveled. Why not try rehabilitation?","volume":"13","author":"Glass LE","year":"1992","journal-title":"SHHH J"},{"key":"e_1_2_1_4_1","volume-title":"Demographic Aspects of Hearing Impairment: Questions and Answers","author":"Hotchkiss D","year":"1989"},{"key":"e_1_2_1_5_1","first-page":"1","volume-title":"Genetic and Metabolic Deafness","author":"Konigsmark BW","year":"1976"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.11.5181"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320460504"},{"key":"e_1_2_1_8_1","volume-title":"Computer Applications in Genetics","author":"Morton NE","year":"1969"},{"key":"e_1_2_1_9_1","series-title":"Series 10, Number 166","volume-title":"Data from the National Health Survey","author":"National Center for Health Statistics","year":"1988"},{"key":"e_1_2_1_10_1","unstructured":"RoseSP(1975) \u201cGenetic Studies of Profound Prelingual Deafness.\u201d Ph. D. Thesis Indiana University 1975."}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320540211","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320540211","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T01:27:18Z","timestamp":1698110838000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320540211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,6,15]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1994,6,15]]}},"alternative-id":["10.1002\/ajmg.1320540211"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320540211","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,6,15]]}}}