{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T16:43:30Z","timestamp":1726245810589},"reference-count":67,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,6,3]],"date-time":"2005-06-03T00:00:00Z","timestamp":1117756800000},"content-version":"vor","delay-in-days":3914,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1994,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Among relatives of Ashkenazi schizophrenic probands the rate of amyotrophic lateral sclerosis was 3\/1,000, compared to expected population rates of approximately 2\/100,000. Relative risk of bleeding disorders, including hematologic cancers, was increased more than three\u2010fold compared to controls. Co\u2010occurrence of motor neuron disease and blood dyscrasias, accompanied by psychosis, has long been recognized. A virally mediated autoimmune pathogenesis has been proposed. However, the familial co\u2010occurrence of these three disease entities raises the possibility that the disease constellation be considered as a manifestation of a common underlying genetic defect. Such expansion of the spectrum of affectation might enhance the power of both candidate gene and linkage studies. Based on these findings the loci suggested as candidate regions in schizophrenia include a potential hot spot on chromosome 21q21\u2010q22, involving the superoxide dismutase and amyloid precursor protein genes. Alternatively, genes on other chromosomes involved in the expression, transcription, or regulation of these genes, or associated with the illnesses of high frequency in these pedigrees are suggested. Candidates include the choroid plexus transport protein, transthyretin at 18q 11.2\u2010q12.1; the t(14;18)(q22;21) characterizing B\u2010cell lymphoma\u20102, the most common form of hematologic cancer; and the 14q24 locus of early onset Alzheimer's disease, c\u2010Fos, transforming growth factor beta 3, and heat shock protein A2. Expression of hematologic cancers and the suggested candidate genes are known to involve retinoid pathways, and retinoid disregulation has been proposed as a cause of schizophrenia. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.1320540317","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T17:52:51Z","timestamp":1118512371000},"page":"271-278","source":"Crossref","is-referenced-by-count":16,"title":["Elevated risks for amyotrophic lateral sclerosis and blood disorders in Ashkenazi schizophrenic pedigrees suggest new candidate genes in schizophrenia"],"prefix":"10.1002","volume":"54","author":[{"given":"Ann B.","family":"Goodman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1991.00530180041015"},{"key":"e_1_2_1_3_1","first-page":"150","volume-title":"Genetic Diversity Among Jews","author":"Asakai R","year":"1992"},{"issue":"3","key":"e_1_2_1_4_1","first-page":"123","article-title":"A linkage study of bipolar disease","volume":"3","author":"Berrettini WH","year":"1993","journal-title":"Abstract Psychiatr Genet"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410250104"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1993.01820150074008"},{"key":"e_1_2_1_7_1","first-page":"80","volume-title":"Genetic Diversity Among Jews","author":"Bonne\u2010Tamir B","year":"1992"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-3182(81)73549-7"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/19.4.747"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/2.3.321"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320480109"},{"issue":"3","key":"e_1_2_1_12_1","first-page":"124","article-title":"Linkage studies with bipolar disorder in two Belgian families","volume":"3","author":"DeBruyn A","year":"1993","journal-title":"Abstract Psychiatc Genet"},{"issue":"3","key":"e_1_2_1_13_1","first-page":"176","article-title":"Affective disorder in families with schizophrenia","volume":"3","author":"DeLisi LE","year":"1993","journal-title":"Psychiatr Genet"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/347558a0"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.6.1136"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1546291"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00688180"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.60.070191.001541"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.6.2375"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/mend-3-10-1610"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/349704a0"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/20.3.507"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.151.3.452b"},{"key":"e_1_2_1_24_1","unstructured":"GoodmanABEpidemiological clinical and biochemical evidence suggest a role for gangliosides in the etiology of schizophrenia. 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