{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T12:38:01Z","timestamp":1772800681425,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,6,8]],"date-time":"2005-06-08T00:00:00Z","timestamp":1118188800000},"content-version":"vor","delay-in-days":3828,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1994,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Transmission studies have supported the presence of a susceptibility gene for bipolar (BP) illness on the X\u2010chromosome. Initial linkage studies with color blindness (CB), glucose\u20106\u2010phosphate dehydrogenase (G6PD) deficiency, and the blood coagulation factor IX (F9) have suggested that a gene for BP illness is located in the Xq27\u2010q28 region. We tested linkage with several DNA markers located in Xq27\u2010q28 in 2 families, MAD3 and MAD4, that previously were linked to F9 and 7 newly ascertained families of BP probands. Linkage was also examined with the gene encoding the \u03b13 subunit of the gamma\u2010amino butyric acid receptor (GABRA3), a candidate gene for BP illness located in this region. The genetic data were analyzed with the LOD score method using age\u2010dependent penetrance of an autosomal dominant disease gene and narrow and broad clinical models. In MAD3 and MAD4 the multipoint LOD score data suggested a localization of a BPI gene again near F9. In the 7 new families the overall linkage data excluded the Xq27\u2010q28 region. However, if the families were grouped according to their proband's phenotype BPI or BPII, a susceptibility gene for BPI disorder at the DXS52\u2010F8 cluster could not be excluded. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.1320540423","type":"journal-article","created":{"date-parts":[[2006,2,4]],"date-time":"2006-02-04T04:24:47Z","timestamp":1139027087000},"page":"411-419","source":"Crossref","is-referenced-by-count":13,"title":["Linkage analysis of bipolar illness with X\u2010chromosome DNA markers: A susceptibility gene in Xq27\u2010q28 cannot be excluded"],"prefix":"10.1002","volume":"54","author":[{"given":"A.","family":"De Bruyn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Raeymaekers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Mendelbaum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. 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