{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:18:53Z","timestamp":1760782733399},"reference-count":4,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,5,16]],"date-time":"2005-05-16T00:00:00Z","timestamp":1116201600000},"content-version":"vor","delay-in-days":3745,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1995,2,13]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A chromosomal translocation between chromosomes 4 and 8 resulting in Wolf\u2010Hirschhorn syndrome in 2 individuals has been traced through 4 generations of a family. Ascertainment of the family was through a newborn infant with evident Wolf\u2010Hirschhorn syndrome who had an unbalanced chromosomal translocation [46,XY,\u22124,+der(4),t(4;8) (p15.32;p22)]. Discussion with the family documented a paternal great\u2010uncle who also had a similar phenotype and profound mental retardation. Subsequently this individual was found to have the same unbalanced chromosome constitution as the propositus. The 39\u2010year\u2010old great\u2010uncle is the oldest reported individual with the Wolf\u2010Hirschhorn syndrome. The importance of chromosome evaluation of older individuals with mental retardation syndromes is emphasized. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.1320550414","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T17:54:26Z","timestamp":1118512466000},"page":"462-465","source":"Crossref","is-referenced-by-count":16,"title":["Familial translocation resulting in Wolf\u2010Hirschhorn syndrome in two related unbalanced individuals: Clinical evaluation of a 39\u2010year\u2010old man with Wolf\u2010Hirschhorn syndrome"],"prefix":"10.1002","volume":"55","author":[{"given":"Patricia G","family":"Wheeler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David D.","family":"Weaver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine G.","family":"Palmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,16]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1975.02120400066017"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1987.tb02825.x"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1984.tb00494.x"},{"key":"e_1_2_1_5_1","first-page":"224","article-title":"Clinical and cytogenetic studies in a large (4;8) translocation family with pre\u2010and postnatal Wolf syndrome","volume":"27","author":"Tranebjaerg L","year":"1984","journal-title":"Ann Genet"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320550414","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320550414","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T21:30:05Z","timestamp":1698355805000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320550414"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,2,13]]},"references-count":4,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1995,2,13]]}},"alternative-id":["10.1002\/ajmg.1320550414"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320550414","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,2,13]]}}}