{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T02:38:34Z","timestamp":1785465514031,"version":"3.56.0"},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,6,3]],"date-time":"2005-06-03T00:00:00Z","timestamp":1117756800000},"content-version":"vor","delay-in-days":3721,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1995,3,27]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Polysomnographic recordings of 43 children and adults with Prader\u2010Willi syndrome (PWS) were inspected and classified into 5 age groups. The effect of age and body mass index (BMI) on measures of breathing, oxygen saturation, and sleep efficiency were analyzed. Body mass index (BMI) increased significantly between early childhood and preadolescent groups. Subjecting the data to analysis of variance showed an overall significant effect of BMI but no age effect on breathing parameters and oxygen saturation. Increased BMI was associated with decreased oxygen saturation and with higher apnea\/hypopnea index. Sleep efficiency index was significantly lower in adults than in young children, preadolescent, and adolescent groups. These findings emphasize the role of obesity in the development of sleep\u2010related breathing abnormalities and nocturnal oxygen desaturation in patients with PWS. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.1320560215","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T17:59:25Z","timestamp":1118512765000},"page":"188-190","source":"Crossref","is-referenced-by-count":78,"title":["Developmental trends of sleep\u2010disordered breathing in Prader\u2010Willi syndrome: The role of obesity"],"prefix":"10.1002","volume":"56","author":[{"given":"Gila","family":"Hertz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Cataletto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven H.","family":"Feinsilver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moris","family":"Angulo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197903083001001"},{"key":"e_1_2_1_3_1","first-page":"1","volume-title":"Prader Willi Syndrome and Other Chromosome 15q Deletion Disorders","author":"Cassidy SB","year":"1989"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-0316-9_6"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1093\/sleep\/3.3-4.441","article-title":"Medroxyprogesterone treatment of obstructive sleep apnea","volume":"3","author":"Hansley MJ","year":"1980","journal-title":"Sleep"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.79.3.256"},{"issue":"4","key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1093\/sleep\/16.4.366","article-title":"Sleep and breathing patterns in patients with Prader Willi syndrome: Effects of age and gender","volume":"16","author":"Hertz G","year":"1993","journal-title":"Sleep"},{"issue":"2","key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1542\/peds.91.2.398","article-title":"Prader Willi syndrome: Consensus diagnostic criteria","volume":"91","author":"Holm VA","year":"1993","journal-title":"Pediatrics"},{"key":"e_1_2_1_9_1","first-page":"211","article-title":"Nocturnal hypoxia and sleep apnea in asymptomatic obese men","volume":"10","author":"Kopelman PG","year":"1986","journal-title":"Int J Obesity"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(89)80738-3"},{"key":"e_1_2_1_11_1","volume-title":"Electroencephalography (EEG) of Human Sleep","author":"Williams RL","year":"1974"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320560215","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320560215","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T15:02:41Z","timestamp":1698332561000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320560215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,3,27]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1995,3,27]]}},"alternative-id":["10.1002\/ajmg.1320560215"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320560215","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,3,27]]}}}