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Genet."],"published-print":{"date-parts":[[1995,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To investigate the relationship between congenital heart disease and jugular lymphatic obstruction as manifested in web neck anomaly, we used the Iowa Birth Defects Registry to determine the incidence of congenital heart defects (CHD) in infants with and without web neck.<\/jats:p><jats:p>Sixty percent of infants with web neck had CHD, with a high incidence of flowrelated defects such as hypoplastic left heart, coarctation, and secundum atrial septal defect. Sixty\u2010eight percent of infants with web neck had a genetic syndrome (37% Down syndrome, 13% Ullrich\u2010Turner syndrome, and 5% Noonan syndrome), and 24% had dysmorphic features consistent with lymphatic obstruction sequence. When infants with Down, Ullrich\u2010Turner, and Noonan syndrome and web neck were compared to infants with the same syndrome but without web neck, those with web neck were significantly more likely to have flow\u2010related heart defects. Infants with Ullrich\u2010Turner syndrome and web neck had an 11\u2010fold higher incidence of coarctation, compared to those with a normal neck.<\/jats:p><jats:p>Our data suggests web neck is associated with both flow and nonflow\u2010related heart defects. This association implies a pathogenetic relationship and appears to be independent of causal factors. The finding of web neck or nuchal cystic hygroma on a prenatal ultrasound or newborn examination should prompt a search for CHD. \u00a9 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.1320560318","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T18:00:26Z","timestamp":1118512826000},"page":"304-307","source":"Crossref","is-referenced-by-count":46,"title":["Web neck anomaly and its association with congenital heart disease"],"prefix":"10.1002","volume":"56","author":[{"given":"Laurie D.","family":"Berdahl","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharine D.","family":"Wenstrom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James W.","family":"Hanson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.66.2.281"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(84)80331-7"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198310063091403"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420290305"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-2305-1_1"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a113979"},{"key":"e_1_2_1_8_1","first-page":"203","article-title":"Coarctation of the aorta explained as a branch point of the ductus arteriosus","volume":"63","author":"Hutchins GM","year":"1971","journal-title":"Am J Pathol"},{"key":"e_1_2_1_9_1","first-page":"445","article-title":"Coarctation of the aorta in Turner syndrome: a pathologic study of fetuses with nuchal cystic hygromas, hydrops fetalis, and female genitalia","volume":"81","author":"Lacro RV","year":"1988","journal-title":"Pediatrics"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(88)80591-2"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320340408"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(72)90042-2"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4831-9949-8.50012-2"},{"key":"e_1_2_1_14_1","volume-title":"Current Paediatric Cardiology","author":"Shinebourne EA","year":"1980"},{"key":"e_1_2_1_15_1","first-page":"472","volume-title":"Recognizable Patterns of Human Malformation: Genetic, Embryologic and Clinical Aspects","author":"Smith DW","year":"1982"},{"key":"e_1_2_1_16_1","unstructured":"SweeneyLJ(1981):Morphometric analysis of an experimental model of left heart hypoplasia in the chickPh. 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