{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T06:06:09Z","timestamp":1761717969967},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,6,7]],"date-time":"2005-06-07T00:00:00Z","timestamp":1118102400000},"content-version":"vor","delay-in-days":3706,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1995,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Segment 4q33 is not considered a probable location of a gene related with limb deficiency by Roberts and Tabin [Am J Hum Genet 55:1\u20136, 1994]; however, the occurrence of ectrodactyly or its equivalents in at least 9 published cases of monosomy 4q33 suggests probable location of one of these genes in that region. Ulnar ray defects and\/or ectrodactyly were the prevailing forms. An additional loss of the tip of 4p in patients with ring chromosome 4 leads to a change of limb deficiency type: 8 of 9 patients with r(4) and limb deficiency had radial ray defects. Therefore, interactions between a proposed \u00bd dose \u201cectrodactyly\u201d gene on 4q33 and some \u00bd dosage genes on distal 4p (or disturbed cellular homeostasis due to a ring chromosome 4) can change the developmental pattern of limb deficiency. Possible mechanisms and significance of the Phenomenon are discussed. \u00a9 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.1320560319","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T18:00:26Z","timestamp":1118512826000},"page":"308-311","source":"Crossref","is-referenced-by-count":12,"title":["Further study of genetic interactions: Loss of short arm material in patients with ring chromosome 4 changes developmental pattern of del(4)(q33)"],"prefix":"10.1002","volume":"56","author":[{"given":"Iosif W.","family":"Lurie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,7]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"23","article-title":"Partial trisomy 8q22.3\u2192qter","volume":"7","author":"Albiez KL","year":"1988","journal-title":"Proc Greenwood Genet Center"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-999532"},{"key":"e_1_2_1_4_1","first-page":"459","article-title":"Eine junge Frau mit Symptomen des Wolf\u2010Hirschhorn\u2010Syndroms und einem Ringchromosom 4","volume":"46","author":"Belitz B","year":"1991","journal-title":"Z Klin Med"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320250302"},{"key":"e_1_2_1_6_1","first-page":"135","article-title":"Reduction malformations and chromosome anomalies","volume":"125","author":"Bofinger MK","year":"1973","journal-title":"Am J Dis Child"},{"key":"e_1_2_1_7_1","first-page":"406","article-title":"Interstitial deletion of 2q24.2\u2010q31.1 causes characteristic limb malformations","volume":"53","author":"Boles RG","year":"1993","journal-title":"Am J Hum Genet [Suppl]"},{"key":"e_1_2_1_8_1","first-page":"410","article-title":"Interstitial deletion of 6q associated with ectrodactyly","volume":"53","author":"Braverman N","year":"1993","journal-title":"Am J Hum Genet Suppl"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.6.2.224"},{"issue":"5","key":"e_1_2_1_10_1","first-page":"114","article-title":"A ring B chromosome in a female with multiple skeletal abnormalities","volume":"5","author":"Dallaire L","year":"1969","journal-title":"BD:OAS"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00283580"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.6.3.342"},{"key":"e_1_2_1_13_1","first-page":"261","article-title":"Le syndrome de d\u00e9l\u00e9tion terminale du bras long du chromosome 4","volume":"38","author":"Frappaz D","year":"1983","journal-title":"Pediatrie"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0393-247"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1033986"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1984.tb02003.x"},{"key":"e_1_2_1_17_1","first-page":"169","article-title":"Symbrachydactyly: Pathogenesis of the 5\u2010fluorouracil induced model in mice","volume":"29","author":"Imagawa S","year":"1980","journal-title":"Hiroshima J Med Sci"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00591082"},{"key":"e_1_2_1_19_1","first-page":"198","article-title":"Chromosomally normal parents with two children having different autosomal deletion syndromes","volume":"4","author":"Kushnick T","year":"1988","journal-title":"Am J Med Genet Suppl"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320310308"},{"key":"e_1_2_1_21_1","first-page":"404","article-title":"Delecci\u00f3n terminal de brazo largo del cromosoma 4: 46,XY,del(4)(q31.3\u2192qter): Un caso tras fertilizaci\u00f3n in vitro","volume":"35","author":"Lizarraga Azparren MA","year":"1991","journal-title":"Anal Esp Pediatr"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320470323"},{"key":"e_1_2_1_23_1","unstructured":"LurieIW GurevichDB AutkoNI(1986):Del(2)(q31q33) syndrome. 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