{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T03:16:43Z","timestamp":1791170203850,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,6,9]],"date-time":"2005-06-09T00:00:00Z","timestamp":1118275200000},"content-version":"vor","delay-in-days":3671,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1995,5,22]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sturge\u2010Weber syndrome (SWS) is a neuro\u2010cutaneous disorder characterized by cutaneous facial angioma, leptomeningeal angioma associated with seizures and other neurologic complications including mental retardation, and glaucoma. Only limited information about long\u2010term outcome, including the societal integration of adult patients, is available in the literature.<\/jats:p><jats:p>Data on 52 adults with SWS, ages 18\u201063 years, ascertained through the Sturge\u2010Weber Foundation, were obtained via written questionnaires, telephone interviews, and reviews of medical records. The distribution of port\u2010wine stains (cranial 98%, extracranial 52%) and the prevalences of glaucoma (60%), seizures (83%), neurologic deficit (65%), and other complications were established. The age of onset of glaucoma (0\u201041 years), the age of onset of seizures (0\u201023 years), and the correlation between the distribution of port\u2010wine stains and the prevalence of seizures was identified. The relationship between the age of onset of seizures and seizure control was established. In those with and without seizures, the prevalences of developmental delay (43% vs. 0%), emotional and behavior problems (85% vs. 58%), special education requirements (71% vs. 0%), and employability (46% vs. 78%) were analyzed. Overall, 39% were financially self\u2010sufficient, and 55% were or could be married. Ten participants produced 20 liveborn offspring; 17 were healthy, and tuberous sclerosis, a caf\u00e9\u2010au\u2010lait spot, and a \u201cbirthmark\u201d were found in 1 child each. The results of this study can be used for genetic counseling in Sturge\u2010Weber syndrome. Adults, emotional problems, behavior problems, offspring, education, employment, genetic counseling \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.1320570110","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T13:31:34Z","timestamp":1118496694000},"page":"35-45","source":"Crossref","is-referenced-by-count":216,"title":["Outcome of Sturge\u2010Weber syndrome in 52 adults"],"prefix":"10.1002","volume":"57","author":[{"given":"Eva","family":"Sujansky","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Conradi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6,9]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"1","volume-title":"The Sturge\u2010Weber Syndrome.","author":"Alexander 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