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Genet."],"published-print":{"date-parts":[[1995,6,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>CD4+, CD8+, and CD56+ cells were isolated with the immunomagnetic separation technique from peripheral blood mononuclear cells (PBMC) of 3 patients with neuronal ceroid\u2010lipofuscinosis: one patient each with infantile (INCL), late infantile (LINCL), and juvenile (JNCL) neuronal ceroid\u2010lipofuscinoses, all studied by light (LM) and electron (EM) microscopy. To compare the pathology of these cells with affected cells in other types of lysosomal diseases, the separation was also performed with PBMC of 1 patient with mucolipidosis (ML) type II, 2 patients with mucopolysaccharidosis (MPS) type I, and 4 patients with MPS type III. Diseasespecific lysosomal inclusions were identified in CD4+, CD8+, and CD56+ cells. Subclass\u2010specific storage products could not be found. T4 and T8 lymphocytes showed nearly the same ratio of affected to nonaffected cells.<\/jats:p><jats:p>These results suggest that lysosomal storage can be found in most of the lymphocyte subclasses in these forms of neuronal ceroid\u2010lipofuscinoses and other lysosomal diseases. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.1320570221","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T18:01:48Z","timestamp":1118512908000},"page":"222-224","source":"Crossref","is-referenced-by-count":4,"title":["Immunelectronmicroscopic characterization of T4 and T8 lymphocytes and natural killer cells in neuronal ceroid\u2010lipofuscinosis"],"prefix":"10.1002","volume":"57","author":[{"given":"Bernd C.","family":"Kieseier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans Hilmar","family":"Goebel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,9]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"263","article-title":"Distribution of cytoplasmic vacuoles in blood T and B lymphocytes in two lysosomal disorders","volume":"18","author":"Aula P","year":"1975","journal-title":"Virchows Arch [B]"},{"key":"e_1_2_1_3_1","first-page":"1","article-title":"Separation of leucocytes from blood and bone marrow","volume":"97","author":"B\u00f6yum A","year":"1968","journal-title":"Scand J Clin Lab Invest [Suppl]"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.1991.tb00717.x"},{"key":"e_1_2_1_5_1","first-page":"487","article-title":"Lymphocytes and urine in ceroid lipofuscinosis","volume":"104","author":"Dolman CL","year":"1980","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_1_6_1","first-page":"109","article-title":"Adult neuronal ceroid\u2010lipofuscinosis. 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