{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T21:01:33Z","timestamp":1790974893954,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,5,16]],"date-time":"2005-05-16T00:00:00Z","timestamp":1116201600000},"content-version":"vor","delay-in-days":3549,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1995,8,28]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Congenital \u201chealed\u201d cleft lip (CHCL) is an unusual anomaly including a paramedian \u201cscar\u201d of the upper lip, which appears as if a typical cleft lip has been corrected <jats:italic>in utero<\/jats:italic>. The CHCL is frequently associated with an ipsilateral notch in the vermilion, and \u201ccollapsed\u201d nostril.<\/jats:p><jats:p>Twenty\u2010five CHCL cases are presented, eighteen of which were an isolated malformation found among the 3,950,715 births examined in two similar birth defect registries: ECEMC in Spain and ECLAMC in Latin America.<\/jats:p><jats:p>Like open cleft lip, of which it seems to be a variant, CHCL is most frequently seen among males (14\/18 isolated cases), it preferentially affects the left side (10\/18 cases), and it segregated together with cleft lip in one family.<\/jats:p><jats:p>The five CHCL cases with other congenital anomalies included: two cases with hydrocephalus, two VACTERL associations, and one atypical oblique facial cleft infant with single umbilical artery.<\/jats:p><jats:p>CHCL may result from a defective fusion of the frontonasal and maxillary processes (before week 7 of embryonic life), or from a spontaneously repaired open cleft lip, later on. In either way, these cases heal with a visible scar, and the pre\u2010occurrence of CHCL in two families suggests a familial predisposition to this phenomenon. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.1320580203","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T18:04:36Z","timestamp":1118513076000},"page":"106-112","source":"Crossref","is-referenced-by-count":22,"title":["Congenital healed cleft lip"],"prefix":"10.1002","volume":"58","author":[{"given":"Eduardo E.","family":"Castilla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Lu\u00edsa","family":"Mart\u00ednez\u2010Fr\u00edas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,5,16]]},"reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/0007-1226(92)90055-3"},{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320410232"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1937.01480010023003"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-75599-6_6"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-196104000-00001"},{"key":"e_1_2_1_6_1","first-page":"129","volume-title":"Congenital Malformations Worldwide","author":"International Clearinghouse for Birth Defects Monitoring Systems","year":"1991"},{"key":"e_1_2_1_7_1","first-page":"147","volume-title":"Smith's Recognizable Patterns of Human Malformations","author":"Jones KL","year":"1988"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569(1993)030<0013:FCLRIR>2.3.CO;2"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-197609000-00008"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199211000-00003"},{"key":"e_1_2_1_11_1","unstructured":"Lopez\u2010CameloJS OrioliIM: Heterogeneous rates for birth defects in South America: Some hints on causality.Eur J Epidemiol\u201cin press\u201d."},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320470529"},{"key":"e_1_2_1_13_1","first-page":"744","article-title":"Developmental field defects and associations: Epidemiological evidence for their relationship","volume":"47","author":"Mart\u00ednez Fr\u00edas ML","year":"1994","journal-title":"Am J Med Genet"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320490109"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0901-5027(88)80029-8"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320200404"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0503(76)80013-6"},{"key":"e_1_2_1_18_1","first-page":"223","volume-title":"Birth Defect Compendium","author":"Witkop CJ","year":"1979"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320580203","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320580203","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T17:40:17Z","timestamp":1698342017000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320580203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,8,28]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1995,8,28]]}},"alternative-id":["10.1002\/ajmg.1320580203"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320580203","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,8,28]]}}}