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The deletion of chromosome 13 was interpreted as terminal with a breakpoint at 13q32.3. Coagulation factors VII and X located in 13q34, were markedly reduced in the propositus.<\/jats:p><jats:p>Although there is some clinical overlap between patients with terminal deletion of 13q and those with the Opitz GBBB syndrome, our patient manifests a whole pattern of abnormalities characteristic of the latter disorder. The concurrence of the Opitz GBBB syndrome and the chromosome abnormality in our patient could be due to chance or, be becuase a gene for the Opitz GBBB syndrome is located at the tip of 13q. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.1320590123","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T18:09:09Z","timestamp":1118513349000},"page":"114-122","source":"Crossref","is-referenced-by-count":8,"title":["Distal deletion of chromosome 13 in a child with the \u201cOpitz\u201d GBBB syndrome"],"prefix":"10.1002","volume":"59","author":[{"given":"Miguel","family":"Urioste","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Arroyo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia","family":"Villa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Lorda\u2010S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Barrio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda\u2010Jes\u00fas","family":"L\u00f3pez\u2010Cuesta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Rueda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,5,16]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1981.02130360023009"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00201741"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320450115"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320280207"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320370324"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1979.tb01013.x"},{"key":"e_1_2_1_8_1","first-page":"755","volume-title":"Birth Defects Encyclopedia","author":"Gilbert\u2010Barnes EF","year":"1990"},{"key":"e_1_2_1_9_1","first-page":"32","article-title":"Structural genes of coagulation factors VII and X located on 13q34","volume":"29","author":"Gilgenkrantz S","year":"1986","journal-title":"Ann G\u00e9n\u00e9t"},{"key":"e_1_2_1_10_1","first-page":"792","volume-title":"Syndromes of the Head and Neck","author":"Gorlin RJ","year":"1990"},{"key":"e_1_2_1_11_1","first-page":"367","volume-title":"Birth Defects Encyclopedia","author":"Hawks PA","year":"1990"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.15.1.48"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320400225"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320400210"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320490109"},{"key":"e_1_2_1_16_1","first-page":"575","volume-title":"Mendelian Inheritance in Man. 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