{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:19:47Z","timestamp":1762100387018},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,6,7]],"date-time":"2005-06-07T00:00:00Z","timestamp":1118102400000},"content-version":"vor","delay-in-days":3697,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1995,4,24]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cytogenetic analysis was carried out in unrelated schizophrenic patients, unrelated controls and patients and family members in multiplex families. The size distribution of chromosome 1 heterochromatic region (1qH, C\u2010band variants) among 21 unrelated schizophrenic patients was different from that found in a group of 46 controls. The patient group had 1qH variants of smaller size than the control group (<jats:italic>P<\/jats:italic> &lt; 0.01). Incubation of phytohemagglutinin\u2010treated blood lymphocytes with 5\u2010azacytidine (which causes decondensation and extension of the heterochromatin) led to a lesser degree of heterochromatin decondensation in a group of patients than in the controls (7 schizophrenic, 9 controls, <jats:italic>P<\/jats:italic> &lt; 0.01). The distribution of phenotypes of Duffy blood group system [whose locus is linked to the 1qH region (Donahue et al.: Proc Natl Acad Sci USA 61:949\u2013955, 1968; Rouleau et al.: Genomics 7:313\u2013318, 1990)] among 28 schizophrenic patients was also different from that in the general population. Cosegregation of schizophrenia with a 1qH (C\u2010band) variant and Duffy blood group allele was observed in one of six multiplex families. The overall results suggest that alterations within the Duffy\/1qH region are involved in schizophrenia in some cases. This region contains the locus of D5 dopamine receptor pseudogene 2 (1q21.1), which is transcribed in normal lymphocytes (Takahashi et al.: FEBS Lett 314:23\u201325, 1992). \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.1320600209","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T18:17:45Z","timestamp":1118513865000},"page":"133-138","source":"Crossref","is-referenced-by-count":46,"title":["Constitutive heterochromatin of chromosome 1 and Duffy blood group alleles in schizophrenia"],"prefix":"10.1002","volume":"60","author":[{"given":"N. S.","family":"Kosower","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Gerad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Goldstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Parasol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Zipser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Ragolsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Rozencwaig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Elkabetz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Abramovitch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Lerer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Weizman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,7]]},"reference":[{"key":"e_1_2_1_2_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders (DSM\u2010III\u2010R)","author":"American Psychiatric Association","year":"1987"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01675211"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7696(08)61435-7"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.161.3.323"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00527402"},{"key":"e_1_2_1_7_1","first-page":"324","article-title":"Analysis of genetic data on Jewish populations. I Historical background, demographic features and genetic markers","volume":"31","author":"Bonne\u2010Tamir B","year":"1979","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_8_1","first-page":"1","article-title":"Use of polymerase chain reaction and denaturing gradient gel electrophoresis to identify polymorphisms in three exons of dopamine receptor gene in schizophrenic and delusional patients","volume":"26","author":"Catalano M","year":"1992","journal-title":"Biol Psychiatry"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.61.3.949"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1978.01770310043002"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00276592"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1991.306"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.6.7.1348713"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(92)90009-H"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320260116"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-9525(90)90304-O"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/19.2.261"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2274784"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00295805"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-65787-0_1"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00418396"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(90)90163-O"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.1370070408"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1979.tb02267.x"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00388461"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511983603.005"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/365441a0"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320480207"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(87)90286-2"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1978.01770300115013"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(92)81452-R"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0920-9964(91)90031-L"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320480205"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.30.2.131"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320600209","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320600209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T22:36:05Z","timestamp":1698359765000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320600209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,4,24]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1995,4,24]]}},"alternative-id":["10.1002\/ajmg.1320600209"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320600209","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,4,24]]}}}