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A hypothesis is proposed that a major TS gene is probably connected to genetic instability, and associated chromosomal marker sites may be indicative of the localization of secondary genes whose altered expression could be responsible for associated comorbid conditions. This concept implies that genes influencing higher brain functions may be situated at or near highly recombigenic areas allowing enhanced amplification, duplication and recombination following chromosomal strand breakage. Further studies on a larger sample size are required to confirm the findings relating to chromosomal breakage and to analyze the possible implications for a paradigmatic shift in linkage strategy for complex disorders by focusing on areas at or near unstable chromosomal marker sites. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.1320600516","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T18:21:27Z","timestamp":1118514087000},"page":"444-447","source":"Crossref","is-referenced-by-count":13,"title":["Increased chromosomal breakage in tourette syndrome predicts the possibility of variable multiple gene involvement in spectrum phenotypes: Preliminary findings and hypothesis"],"prefix":"10.1002","volume":"60","author":[{"given":"George S.","family":"Gericke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid","family":"Simonic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elma","family":"Cloete","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecile","family":"Buckle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piet J.","family":"Becker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/088307388600100407"},{"key":"e_1_2_1_3_1","first-page":"111","article-title":"Segregation analysis of autosomal fragile sites in three families with fragile X chromosome","volume":"34","author":"Barletta C","year":"1991","journal-title":"Ann Genet"},{"key":"e_1_2_1_4_1","first-page":"767","article-title":"Genetic analysis of Tourette syndrome suggesting major gene defect","volume":"36","author":"Baron M","year":"1981","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)92555-V"},{"key":"e_1_2_1_6_1","unstructured":"ComingsDE ComingsBG DietzG MuhlemanD OkadaTA SarinanaF SimmerR StockD(1986):Evidence the Tourette syndrome gene is at 18q21.1. 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