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Half of affected relatives had motor coordination deficits; and they came from families in which probands also showed impaired motor coordination. By contrast, affected relatives without motor deficits came from dyslexia families where probands did not have motor deficits. Motor coordination deficits were more common and more severe among affected offspring in families where both parents were affected than among affected offspring in families where only one parent was affected. However, motor coordination deficits were also more common and more severe in affected <jats:italic>parents<\/jats:italic> when both parents were affected than among affected parents in families where only one parent was affected.<\/jats:p><jats:p>We conclude that impaired temporal resolution in motor action identifies a behavioral phenotype in some subtypes of developmental dyslexia. The observed pattern of transmission for motor deficits and reading impairment in about half of dyslexia families was most congruent with a genetic model of dyslexia in which 2 codominant major genes cosegregate in dyslexia pedigrees where the proband is also motorically impaired. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.1320600604","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T18:25:30Z","timestamp":1118514330000},"page":"494-505","source":"Crossref","is-referenced-by-count":26,"title":["Family patterns of developmental dyslexia, part II: Behavioral phenotypes"],"prefix":"10.1002","volume":"60","author":[{"given":"Peter H.","family":"Wolff","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilze","family":"Melngailis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mateo","family":"Obregon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha","family":"Bedrosian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.157.5.645"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1987.tb03337.x"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1973.tb05180.x"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/002221948601900813"},{"key":"e_1_2_1_6_1","first-page":"391","volume-title":"The World's Major Languages","author":"Corbett G","year":"1990"},{"key":"e_1_2_1_7_1","series-title":"Ann NY Acad Sci","first-page":"23","volume-title":"A neurologist's overview of developmental dyslexia","author":"Denckla MB","year":"1993"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-9452(74)80009-2"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3932(76)90075-0"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/02643298508252865"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1976.tb00161.x"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1985.04060050026008"},{"key":"e_1_2_1_13_1","first-page":"81","volume-title":"Time\u2010series Analysis","author":"Gottman JM","year":"1990"},{"key":"e_1_2_1_14_1","first-page":"2","article-title":"Specific dyslexia (\u201ccongenital word blindness\u201d): a clinical and genetic study","volume":"65","author":"Hallgren B","year":"1950","journal-title":"Acta Psychiatr Neurolog Scand"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278-2626(82)90009-4"},{"key":"e_1_2_1_16_1","unstructured":"HollingsheadAB(1975):Four factor index of social class. 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