{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T23:06:58Z","timestamp":1757545618702},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,6,3]],"date-time":"2005-06-03T00:00:00Z","timestamp":1117756800000},"content-version":"vor","delay-in-days":3455,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1995,12,18]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recently several reports have extended the apolipoprotein E (APOE) \u03f54 association found in late\u2010onset Alzheimer's disease (LOAD) patients to early\u2010onset (EO) AD patients. We have studied this question in a large population of 119 EOAD patients (onset \u2a7d60 years) in which family history was carefully assessed and in 109 controls. We show that the APOE \u03f54 allele frequency is increased only in the subset of patients who belong to families where LOAD secondary cases are present. Our sampling scheme permits us to demonstrate that, for an individual, bearing at least one \u03f54 allele increases both the risk of AD before age 60 and the probability of belonging to a family with late\u2010onset affected subjects. Our results suggest that a subset of EOAD cases shares a common determinism with LOAD cases. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.1320600613","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T18:25:30Z","timestamp":1118514330000},"page":"550-553","source":"Crossref","is-referenced-by-count":22,"title":["Evidence for apolipoprotein E \u03f54 association in early\u2010onset Alzheimer's patients with late\u2010onset relatives"],"prefix":"10.1002","volume":"60","author":[{"given":"Jordi","family":"P\u00e9rez\u2010Tur","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Campion","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexis","family":"Brice","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandrine","family":"Tardieu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Didier","family":"Hannequin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves","family":"Agid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9","family":"Delacourte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7oise","family":"Clerget\u2010Darpoux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie\u2010Christine","family":"Chartier\u2010Harlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.56.1.112-a"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320600202"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320600310"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.1.80"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1292-255"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8346443"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/353844a0"},{"key":"e_1_2_1_9_1","first-page":"567","article-title":"Apolipoprotein E, \u03f54 allele as a major risk factor for sporadic early\u2010 and late\u2010onset forms of Alzheimer's disease: Analysis of the 19q13.2 chromosomal region","volume":"3","author":"Chartier\u2010Harlin MC","year":"1994","journal-title":"Hum Mol Genet"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/349704a0"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)43176-1"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410340527"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0892-345"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1925564"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0594-10b"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.8.1467"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1411576"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.5.1977"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(94)90385-9"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0594-74"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320600613","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320600613","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T19:34:11Z","timestamp":1698262451000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320600613"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,12,18]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1995,12,18]]}},"alternative-id":["10.1002\/ajmg.1320600613"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320600613","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,12,18]]}}}