{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T02:58:50Z","timestamp":1725591530689},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,6,7]],"date-time":"2005-06-07T00:00:00Z","timestamp":1118102400000},"content-version":"vor","delay-in-days":3459,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1995,12,18]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Apoliprotein E, type \u03f54 allele (ApoE\u2010\u03f54) is associated with late\u2010onset sporadic Alzheimer's disease (AD). We have found that the cumulative probability of remaining unaffected over time decreases for each dose of ApoE\u2010\u03f54 in sporadic, late\u2010onset French AD. The effect of genotypes on age at onset of AD was analyzed using the product limit method, to compare unaffected groups during aging. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.1320600617","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T18:25:30Z","timestamp":1118514330000},"page":"566-569","source":"Crossref","is-referenced-by-count":6,"title":["Allele doses of apolipoprotein E type \u03f54 in sporadic late\u2010onset Alzheimer's disease"],"prefix":"10.1002","volume":"60","author":[{"given":"G\u00e9rard","family":"Lucotte","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annie","family":"Aouiz\u00e9rate","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"G\u00e9rard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. C.","family":"Turpin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Landais","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91458-X"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0694-180"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8346443"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.273.5.373"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/372045a0"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)43176-1"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.31.3.197"},{"key":"e_1_2_1_9_1","first-page":"14","article-title":"Familial Alzheimer in France","volume":"35","author":"Lucotte G","year":"1992","journal-title":"Ann Genet"},{"key":"e_1_2_1_10_1","first-page":"1309","article-title":"Apolipoprotein E\u2010\u03f54 allele and Alzheimer's disease","volume":"342","author":"Lucotte G","year":"1993","journal-title":"Lancet"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410360429"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320540319"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3283935"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410340527"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00291670"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91728-5"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1994.03510410028015"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91705-Q"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.8.1513"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(93)90070-8"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)92960-2"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.8.1467"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.5.1977"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)92557-7"},{"key":"e_1_2_1_26_1","first-page":"643","article-title":"Apolipoprotein E: Risk factor for Alzheimer's disease","volume":"54","author":"Tsai MS","year":"1994","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_27_1","first-page":"339","article-title":"Genetics of the apolipoprotein E system in man","volume":"32","author":"Uterman G","year":"1980","journal-title":"Am J Hum Genet"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320600617","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320600617","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T19:34:24Z","timestamp":1698262464000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320600617"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,12,18]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1995,12,18]]}},"alternative-id":["10.1002\/ajmg.1320600617"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320600617","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,12,18]]}}}