{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T11:52:48Z","timestamp":1789905168957,"version":"4.0.1"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2001,4,5]],"date-time":"2001-04-05T00:00:00Z","timestamp":986428800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[2001,4,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recently, we have found an association between bipolar disorder patients who are excellent responders to lithium prophylaxis and a polymorphic marker located in the first intron of the phospholipase C\u2010\u03b31 gene (PLC\u2010\u03b31) [Turecki et al., <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#bib19\">1998<\/jats:ext-link>: Mol Psychiatry 3:534\u2010538]. As this variant is not known to be functional, we searched for other markers within the coding region, using single\u2010strand conformational polymorphism (SSCP) analysis. We have identified three polymorphic sites localized in three different exons of the PLC\u2010\u03b31 gene (exons 9, 26, 31). Variation studies of these potentially functional sites in a group of 133 bipolar patients with an excellent response to lithium prophylaxis and a comparison group of 99 healthy controls showed no difference in genotype distributions for exon 9 (chi\u2010square =\u20091.41, df\u2009=\u20092, <jats:italic>P<\/jats:italic>\u2009=\u20090.49), exon 26 (chi\u2010square =\u20092.26, df\u2009=\u20092, <jats:italic>P<\/jats:italic>\u2009=\u20090.13), or exon 31 (chi\u2010square =\u20091.41, df\u2009=\u20092, <jats:italic>P<\/jats:italic>\u2009=\u20090.49). Similar results were observed for allele distributions. These results suggest that our previous findings were not the result of linkage disequilibrium with these variants. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.1326","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T22:25:53Z","timestamp":1030314353000},"page":"301-305","source":"Crossref","is-referenced-by-count":27,"title":["Identification of three polymorphisms in the translated region of PLC\u2010\u03b31 and their investigation in lithium responsive bipolar disorder"],"prefix":"10.1002","volume":"105","author":[{"given":"Nouzha","family":"Ftouhi\u2010Paquin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Alda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Grof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Chretien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Rouleau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Turecki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,4,5]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.47.1.47"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/341197a0"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.10.9.4770"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(87)90021-2"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1978.01770310043002"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.9.3208"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(94)90066-3"},{"key":"e_1_2_5_9_1","first-page":"799","article-title":"An E\u2010M algorithm and testing strategy for multiple\u2010locus haplotypes","volume":"56","author":"Long JC","year":"1995","journal-title":"Am J Hum Genet"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1995.03950190013003"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.5.2872"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6147898"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2541501"},{"key":"e_1_2_5_14_1","volume-title":"Molecular cloning: a laboratory manual","author":"Sambrook J","year":"1989"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1995.tb01608.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1997.01830130013002"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(99)00076-1"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.14.6554"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1978.01770300115013"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000447"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1326","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1326","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T16:08:13Z","timestamp":1700410093000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1326"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,4,5]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2001,4,8]]}},"alternative-id":["10.1002\/ajmg.1326"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1326","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,4,5]]}}}