{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T23:36:24Z","timestamp":1790552184863,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2002,11,11]],"date-time":"2002-11-11T00:00:00Z","timestamp":1036972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2003,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hereditary hemorrhagic telangiectasia (HHT) has been reported rarely in people of African descent. The prevalence in the Afro\u2010Caribbean population of the Netherlands Antilles is suspected to be high. A family screening in this population was done to arrive at a point prevalence and to identify patients with pulmonary involvement. By clinical history and physical examination, 219 persons over age twelve with a first\u2010degree relative with HHT were screened. The diagnosis was based on the new diagnostic criteria [Shovlin et al., <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#bib24\">2000<\/jats:ext-link>]. Chest\u2010roentgenogram and pulse\u2010oximetry or measurement of arterial oxygen pressure were used to detect pulmonary involvement. HHT was diagnosed in 112 individuals (51%), with at least a point prevalence of 1 in 1,331 inhabitants of Cura\u00e7ao and Bonaire older than twelve years. The diagnosis was uncertain in 27; this was partly due to the new stringent criteria. Epistaxis was present in 98% and telangiectases in 99%. Facial telangiectases were relatively rare due to pigmented skin. Pulmonary involvement was found in 28% with serious\u2014mainly neurological\u2014complications in 48%. The point\u2010prevalence of HHT in the Afro\u2010Caribbean population of the Netherlands Antilles is the highest known in the world. Pulmonary involvement in this population is not rare and causes serious complications. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.a.10002","type":"journal-article","created":{"date-parts":[[2003,1,10]],"date-time":"2003-01-10T21:02:24Z","timestamp":1042232544000},"page":"324-328","source":"Crossref","is-referenced-by-count":110,"title":["The prevalence and manifestations of hereditary hemorrhagic telangiectasia in the Afro\u2010Caribbean population of the Netherlands Antilles: A family screening"],"prefix":"10.1002","volume":"116A","author":[{"given":"Cornelius J.J.","family":"Westermann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahlsen F.","family":"Rosina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"de Vries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela A. de","family":"Coteau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,12,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01073344"},{"key":"e_1_2_6_3_1","first-page":"1116","article-title":"Hereditary hemorrhagic telangiectasis involving the ampulla of Vater presented with recurrent gastrointestinal bleeding","volume":"88","author":"Chu KM","year":"1993","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.165.5.7572487"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s004390000326","article-title":"Two common endoglin mutations in families with hereditary hemorrhagic telangiectasia in the Netherlands Antilles: evidence for a founder effect","volume":"107","author":"Gallione CJ","year":"2000","journal-title":"Hum Genet"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199510053331407"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)80229-0"},{"key":"e_1_2_6_8_1","first-page":"176","article-title":"Epistaxis in hereditary hemorrhagic telangiectasia","volume":"34","author":"Haitjema T","year":"1996","journal-title":"Rhinology"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.32.6.604"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1009384"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0303-8467(93)90123-X"},{"key":"e_1_2_6_12_1","first-page":"917","article-title":"Hereditary hemorrhagic telangiectasia in a Zulu family","volume":"38","author":"Kennedy I","year":"1964","journal-title":"S Afr Med J"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-3019(94)90030-2"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.1999.00398.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.116.2.432"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(97)00815-1"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1294-345"},{"key":"e_1_2_6_18_1","first-page":"1723","article-title":"Maladie de Rendu\u2010Osler dans une grande famille saharienne","volume":"7","author":"Muller JY","year":"1978","journal-title":"Nouv Presse Med"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2001.112682"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.2307\/1532715"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320320302"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.29.8.527"},{"key":"e_1_2_6_23_1","first-page":"389","article-title":"Hereditary hemorrhagic telangiectasia in three black men","volume":"70","author":"Posner DB","year":"1978","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1657518"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(20000306)91:1<66::AID-AJMG12>3.0.CO;2-P"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(54)90142-4"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM194809162391204"},{"key":"e_1_2_6_28_1","unstructured":"TheronAM.1953.Hereditary hemorrhagic telangiectasia: report of a Bantu case. 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