{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T08:33:42Z","timestamp":1791016422234,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2002,10,2]],"date-time":"2002-10-02T00:00:00Z","timestamp":1033516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2003,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The psychological aspects of genetic testing for hereditary breast and ovarian cancer (HBOC) in\n                    <jats:italic>cancer patients<\/jats:italic>\n                    (\n                    <jats:italic>diagnostic<\/jats:italic>\n                    genetic testing) have so far received less attention than\n                    <jats:italic>predictive<\/jats:italic>\n                    genetic testing in\n                    <jats:italic>unaffected<\/jats:italic>\n                    persons. Our study is aimed at gaining insight into the psychological aspects of diagnostic genetic testing and at formulating practical recommendations for counseling. Cancer patients often play a key role in the communication of information to relatives because they were the first individuals to be tested in the family. The present article focuses on the communication to close and distant relatives about the hereditary cancer, the genetic test and its result. Participants previously diagnosed with breast and\/or ovarian cancer, with a family history of these cancers and who requested DNA\u2010testing, were eligible for the study. Of the 83 eligible patients who could be contacted, 63 participated (response rate\u2009=\u200976%). Twenty\u2010six participants were members of a family where a\n                    <jats:italic>BRCA1<\/jats:italic>\n                    or\n                    <jats:italic>BRCA2<\/jats:italic>\n                    mutation was detected. The DNA\u2010analysis in the family of 37 participants had not revealed any mutation. Data were collected by semi\u2010structured interviews and psychological tests and questionnaires. The dissemination of information was largely focused on first\u2010degree relatives. Communication to distant relatives about the genetic test and its result was problematic. Other than the genetic test result and age as \u201cobjective\u201d predictors of informing distant relatives, little and\/or superficial contact seemed to be the major subjective barrier to informing distant relatives. Furthermore, the knowledge about HBOC of these messengers reveals several shortcomings. Communication within the family should receive special attention during counseling. \u00a9 2002 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/ajmg.a.10868","type":"journal-article","created":{"date-parts":[[2002,12,11]],"date-time":"2002-12-11T08:56:05Z","timestamp":1039596965000},"page":"11-19","source":"Crossref","is-referenced-by-count":197,"title":["Communication with close and distant relatives in the context of genetic testing for hereditary breast and ovarian cancer in cancer patients"],"prefix":"10.1002","volume":"116A","author":[{"given":"Erna","family":"Claes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerry","family":"Evers\u2010Kiebooms","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Boogaerts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marleen","family":"Decruyenaere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lieve","family":"Denayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Legius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,10,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0960-8966(93)90118-4"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1025620404473"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19971219)73:3<296::AID-AJMG13>3.0.CO;2-E"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1993.03500150082032"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/88.13.872"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2354.1998.00094.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jncimonographs.a024210"},{"key":"e_1_2_7_9_1","first-page":"393","article-title":"Exploring family relationships in cancer risk counseling using the genogram","volume":"8","author":"Daly M","year":"1999","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5200438"},{"key":"e_1_2_7_11_1","first-page":"149","article-title":"The transfer of information about genetic transmission to brothers and sisters of parents with a CF child","volume":"28","author":"Denayer L","year":"1992","journal-title":"Birth defects"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19970711)71:1<63::AID-AJMG12>3.0.CO;2-T"},{"key":"e_1_2_7_13_1","first-page":"265","article-title":"Breast and ovarian cancer incidence in BRCA1\u2010mutation carriers. 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