{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T04:35:33Z","timestamp":1785818133435,"version":"3.56.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2003,3,27]],"date-time":"2003-03-27T00:00:00Z","timestamp":1048723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2003,4,30]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We present three children with short stature, the same facial phenotype, macrocephaly, enlarged cerebral spinal fluid spaces, short neck with redundant skin, severe GH deficiency, mild psychomotor delay with attention deficit\/hyperactivity disorder (ADHD), mild dilatation of the pulmonary root in two of them, and a unique combination of ectodermal abnormalities. Their appearance, not completely typical of Noonan syndrome, the behavioral phenotype, GH deficiency, darkly pigmented and hairless skin, and the unusual aspect of the hair, defined as loose anagen hair syndrome did not fit any known condition. We postulate that these children may represent a distinct, previously unreported syndrome that we would name \u201cNoonan\u2010like syndrome with loose anagen hair\u201d. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.a.10923","type":"journal-article","created":{"date-parts":[[2003,3,31]],"date-time":"2003-03-31T12:03:18Z","timestamp":1049112198000},"page":"279-286","source":"Crossref","is-referenced-by-count":88,"title":["Noonan\u2010like syndrome with loose anagen hair: A new syndrome?"],"prefix":"10.1002","volume":"118A","author":[{"given":"Laura","family":"Mazzanti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Cacciari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Cicognani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalba","family":"Bergamaschi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Scarano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonino","family":"Forabosco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,3,27]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320210313"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19961218)66:3<347::AID-AJMG20>3.0.CO;2-L"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.23.2.161"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(93)70108-6"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.4.501"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1996.tb01481.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(89)70029-3"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1294-357"},{"key":"e_1_2_5_10_1","first-page":"701","article-title":"Loose anagen hair syndrome","volume":"117","author":"Lalevic\u2010Vasic B","year":"1990","journal-title":"Ann Dermatol Venereol"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320210312"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1995.tb03962.x"},{"key":"e_1_2_5_13_1","first-page":"55","article-title":"Gesteigerte Epilierbarkeit von Anagenhaaren bei Kindern als Folge eines Reifungsdefekts der Follikel mit gest\u00f6rter Verhaftung von Haarschaft und Wurzelscheiden","volume":"12","author":"N\u00f6dl F","year":"1986","journal-title":"Akt Dermatol"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-8628(20001113)95:2<144::AID-AJMG9>3.0.CO;2-E"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320270404"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320390323"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(89)70030-X"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320250303"},{"key":"e_1_2_5_19_1","first-page":"383","article-title":"Developmental and behavioural phenotype in Noonan syndrome?","volume":"11","author":"Sarimski K","year":"2000","journal-title":"Genet Couns"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng772"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.4.521"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000247806"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1997.03890450033004"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-8628(20000904)94:1<46::AID-AJMG10>3.0.CO;2-I"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320420529"},{"key":"e_1_2_5_26_1","first-page":"230","article-title":"CFC syndrome: a syndrome distinct from Noonan syndrome","volume":"31","author":"Verloes A","year":"1988","journal-title":"Ann Genet"},{"key":"e_1_2_5_27_1","first-page":"164","volume-title":"Pediatric dermatology. 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