{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:18:51Z","timestamp":1791497931530,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T00:00:00Z","timestamp":1545868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008113","name":"Indiana University-Purdue University Indianapolis","doi-asserted-by":"publisher","award":["Undergraduate Research Opportunities Grant"],"award-info":[{"award-number":["Undergraduate Research Opportunities Grant"]}],"id":[{"id":"10.13039\/100008113","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE021034"],"award-info":[{"award-number":["DE021034"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008982","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DGE0742475"],"award-info":[{"award-number":["DGE0742475"]}],"id":[{"id":"10.13039\/501100008982","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:p>Feeding and swallowing disorders have been described in children with a variety of neurodevelopmental disabilities, including Down syndrome (DS). Abnormal feeding and swallowing can be associated with serious sequelae such as failure to thrive and respiratory complications, including aspiration pneumonia. Incidence of dysphagia in young infants with DS has not previously been reported. To assess the identification and incidence of feeding and swallowing problems in young infants with DS, a retrospective chart review of 174 infants, ages 0\u20136 months was conducted at a single specialty clinic. Fifty\u2010seven percent (100\/174) of infants had clinical concerns for feeding and swallowing disorders that warranted referral for Videofluroscopic Swallow Study (VFSS); 96\/174 (55%) had some degree of oral and\/or pharyngeal phase dysphagia and 69\/174 (39%) had dysphagia severe enough to warrant recommendation for alteration of breast milk\/formula consistency or nonoral feeds. Infants with certain comorbidities had significant risk for significant dysphagia, including those with functional airway\/respiratory abnormalities (OR\u2009=\u20097.2). Infants with desaturation with feeds were at dramatically increased risk (OR\u2009=\u200915.8). All young infants with DS should be screened clinically for feeding and swallowing concerns. If concerns are identified, consideration should be given to further evaluation with VFSS for identification of dysphagia and additional feeding modifications.<\/jats:p>","DOI":"10.1002\/ajmg.a.11","type":"journal-article","created":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T09:24:25Z","timestamp":1545902665000},"page":"177-182","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":77,"title":["Clinical identification of feeding and swallowing disorders in 0\u20136 month old infants with Down syndrome"],"prefix":"10.1002","volume":"179","author":[{"given":"Maria A.","family":"Stanley","sequence":"first","affiliation":[{"name":"Department of Pediatrics Indiana University School of Medicine  Indianapolis Indiana"},{"name":"Department of Pediatrics University of Wisconsin School of Medicine and Public Health  Madison Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Shepherd","sequence":"additional","affiliation":[{"name":"Department of Biology Indiana University\u2010Purdue University Indianapolis  Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nichole","family":"Duvall","sequence":"additional","affiliation":[{"name":"Department of Biology Indiana University\u2010Purdue University Indianapolis  Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra B.","family":"Jenkinson","sequence":"additional","affiliation":[{"name":"Department of Biology Indiana University\u2010Purdue University Indianapolis  Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasnaa E.","family":"Jalou","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Indiana University School of Medicine  Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah C.","family":"Givan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Indiana University School of Medicine  Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory H.","family":"Steele","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Indiana University Fairbanks School of Public Health  Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlene","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Indiana University School of Medicine  Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilyn J.","family":"Bull","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Indiana University School of Medicine  Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna U.","family":"Watkins","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Indiana University School of Medicine  Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9860-5037","authenticated-orcid":false,"given":"Randall J.","family":"Roper","sequence":"additional","affiliation":[{"name":"Department of Biology Indiana University\u2010Purdue University Indianapolis  Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320470530"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0000000000000415"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-1605"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20393"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddrr.19"},{"key":"e_1_2_9_7_1","first-page":"410","article-title":"Social development and feeding milestones of young Down syndrome children","volume":"85","author":"Cullen S. 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