{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T07:00:31Z","timestamp":1765609231730},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,1,17]],"date-time":"2003-01-17T00:00:00Z","timestamp":1042761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2003,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Glutathione S\u2010transferases (GSTs) play critical roles in providing protection against electrophiles and products of oxidative stress, by catalysing the formation of glutathione conjugates and by eliminating peroxides. Most extensively studied are four main families of human cytosolic GST: GSTAlpha(A), GSTMu(M), GSTPi(P) and GSTTheta(T). Absence of GSTM1 or GSTT1 can be attributed to absence of the GSTM1 or GSTT1 gene products (null genotype) in approximately 50% and 20% of the Caucasian population, respectively. We investigated whether polymorphisms in the GSTM1, GSTT1 and GSTP1 genes modified the risk for chronic pancreatitis (CP). DNA samples were obtained from 142 adult CP patients with alcoholic (n\u2009=\u200979), hereditary (n\u2009=\u200921) or idiopathic (n\u2009=\u200942) origin. DNA from 204 healthy controls and from 57 alcoholic controls was analysed for comparison. Patients and controls were all of Caucasian origin. Genetic polymorphisms in GSTs were determined by PCR, eventually followed by restriction\u2010fragment\u2010length\u2010polymorphism analyses in all subjects. The rates of GSTT1 and GSTP1 genotypes did not differ between CP patients and healthy controls. However, GSTM1 null genotypes were significantly less common in alcoholic CP patients (OR\u2009=\u20090.56, 95% CI: 0.33\u20130.95) as compared to healthy controls and to alcoholic controls (OR\u2009=\u20090.52, 95% CI: 0.26\u20131.04). Age\u2010 and sex\u2010adjustment bolstered our finding (adjusted OR\u2009=\u20090.48, 95% CI: 0.26\u20130.89). The frequency of the GSTM1 null genotype is significantly lower in alcoholic CP patients, especially young female. This suggests that GSTM1 null alcohol users, particularly young female, are less susceptible to CP. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.a.20010","type":"journal-article","created":{"date-parts":[[2003,6,4]],"date-time":"2003-06-04T10:07:08Z","timestamp":1054721228000},"page":"34-39","source":"Crossref","is-referenced-by-count":29,"title":["Glutathione S\u2010transferase mu null genotype affords protection against alcohol induced chronic pancreatitis"],"prefix":"10.1002","volume":"120A","author":[{"given":"Mariette","family":"Verlaan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9 H.M.","family":"te Morsche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hennie M.J.","family":"Roelofs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.F.","family":"Laheij","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan B.M.J.","family":"Jansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilbert H.M.","family":"Peters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joost P.H.","family":"Drenth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,1,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"10004","DOI":"10.1074\/jbc.272.15.10004","article-title":"Molecular cloning characterization, and expression in Escherichia coli of full\u2010length cDNAs of three human glutathione S\u2010transferase Pi gene variants. Evidence for differential catalytic activity of the encoded proteins","volume":"11","author":"Ali\u2010Osman F","year":"1997","journal-title":"J Biol Chem"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008469-199806000-00006"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2423(08)60198-5"},{"key":"e_1_2_6_5_1","first-page":"1004","article-title":"Genotype and phenotype of glutathione S\u2010transferase class mu isoenzymes mu and psi in lung cancer patients and controls","volume":"53","author":"Brockmoller J","year":"1993","journal-title":"Cancer Res"},{"key":"e_1_2_6_6_1","first-page":"573","article-title":"Quantitative analysis of interindividual variation of glutathione S\u2010transferase expression in human pancreas and the ambiguity of correlating genotype with phenotype","volume":"60","author":"Coles BF","year":"2000","journal-title":"Cancer Res"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a010124"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2000.tb00946.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.50.5.687"},{"key":"e_1_2_6_10_1","first-page":"277","volume-title":"Epidemiology","author":"Gordis L","year":"1996"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655201753265479"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-199802000-00004"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/10715769900300851"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/10409239509083491"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000028396"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1383-5742(00)00050-8"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02631-3"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3000271"},{"key":"e_1_2_6_19_1","first-page":"733","article-title":"Molecular Epidemiology of the human glutathione S\u2010transferase genotypes GSTM1 and GSTT1 in cancer susceptibility","volume":"6","author":"Rebbeck TR","year":"1997","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389200003339117"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006676-200105000-00009"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006676-200204000-00013"},{"key":"e_1_2_6_23_1","first-page":"586","article-title":"Polymorphic expression of the glutathione S\u2010transferase P1 gene and its susceptibility to Barrett's esophagus and esophageal carcinoma","volume":"59","author":"van Lieshout EM","year":"1999","journal-title":"Cancer Res"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/19.2.275"},{"key":"e_1_2_6_25_1","first-page":"289","article-title":"Polymorphisms in GSTP1, GSTM1 and GSTT1 and susceptibility to colorectal cancer","volume":"8","author":"Welfare M","year":"1999","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_6_26_1","first-page":"484","article-title":"Lessons from hereditary pancreatitis","volume":"42","author":"Whitcomb DC","year":"2001","journal-title":"Croat Med J"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1096-141"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/76088"}],"container-title":["American Journal of Medical Genetics Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.a.20010","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.a.20010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T21:39:29Z","timestamp":1700170769000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.a.20010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,1,17]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,7]]}},"alternative-id":["10.1002\/ajmg.a.20010"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.a.20010","archive":["Portico"],"relation":{},"ISSN":["1552-4825","1552-4833"],"issn-type":[{"value":"1552-4825","type":"print"},{"value":"1552-4833","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,1,17]]}}}