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Recent reports have associated the use of multivitamin supplements around the time of conception and during early pregnancy with a reduced risk for heart defects in the offspring. We review and discuss the evidence and suggest a framework for further investigation in this area. Published 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.a.20132","type":"journal-article","created":{"date-parts":[[2003,8,5]],"date-time":"2003-08-05T15:49:12Z","timestamp":1060098552000},"page":"95-101","source":"Crossref","is-referenced-by-count":99,"title":["Do multivitamin or folic acid supplements reduce the risk for congenital heart defects? Evidence and gaps"],"prefix":"10.1002","volume":"121A","author":[{"given":"Lorenzo D.","family":"Botto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Mulinare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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