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FISH analysis was carried out on metaphase spreads and interphase lymphocytes from blood smears using a probe specific for the <jats:italic>SHOX<\/jats:italic> gene. Deletion of SHOX was found in four patients (7.1%). No skeletal abnormalities were detected in these patients either at the physical examination or at X\u2010rays of the upper and lower limbs. Present results indicate that SHOX plays an important role also in short stature of unknown cause, and FISH analysis appears as an easy, appropriate, and inexpensive method for the detection of SHOX deletion. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.a.20198","type":"journal-article","created":{"date-parts":[[2003,5,30]],"date-time":"2003-05-30T10:04:53Z","timestamp":1054289093000},"page":"293-296","source":"Crossref","is-referenced-by-count":16,"title":["Deletion of the <i>SHOX<\/i> gene in patients with short stature of unknown 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