{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T23:07:38Z","timestamp":1721603258306},"reference-count":11,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2003,6,16]],"date-time":"2003-06-16T00:00:00Z","timestamp":1055721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2004,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 23\u2010year\u2010old female with Costello syndrome is presented. She had mental retardation, macrocephalia, \u201ccoarse\u201d facial features, deep palmar and plantar creases, hyperkeratosis in palms and soles, hyperpigmentation, curly hair, and cutis laxa, which are among the diagnostic features of the syndrome, and a history of hyperprolactinemia since the age of 16. Her present complaint was weakness and widespread bone\u2010pain. In routine biochemistry, she had an elevated calcium level of 11.1 (8.6\u201310.2) mg\/dl and her DEXA evaluation was consistent with osteoporosis (vertebra and femur <jats:italic>T<\/jats:italic> score &lt;\u22122.5). High PTH levels, 103 (8\u201378) pg\/ml, suggested presence of a parathyroid adenoma. Tc\u2010MIBI scintigraphy revealed two focuses of pathological uptake, one located inferior to left lobe of thyroid and the other in the superior left lobe of thyroid gland. After parathyroid adenomectomy, her serum calcium and PTH levels returned to normal values. This is the first case of parathyroid adenoma and hyperprolactinemia in the literature, reported in a patient with Costello syndrome. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.a.20361","type":"journal-article","created":{"date-parts":[[2003,12,25]],"date-time":"2003-12-25T09:00:29Z","timestamp":1072342829000},"page":"196-199","source":"Crossref","is-referenced-by-count":14,"title":["A case of Costello with parathyroid adenoma and hyperprolactinemia"],"prefix":"10.1002","volume":"124A","author":[{"given":"Mehtap","family":"Cakir","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cumhur","family":"Arici","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sukran","family":"Tacoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umit","family":"Karayalcin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,6,16]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004670050563"},{"key":"e_1_2_4_3_1","first-page":"397","article-title":"A new syndrome","volume":"74","author":"Costello JM","year":"1971","journal-title":"NZ J Med"},{"key":"e_1_2_4_4_1","first-page":"114","article-title":"A new syndrome: Mental subnormality and nasal papillomata","volume":"13","author":"Costello JM","year":"1977","journal-title":"Aust Pediatr J"},{"key":"e_1_2_4_5_1","first-page":"170","article-title":"Costello syndrome","volume":"47","author":"Der Kaloustian VM","year":"1991","journal-title":"Am J Med Genet"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.10241"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1086\/302829"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003072-199511000-00033"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003072-199504000-00025"},{"key":"e_1_2_4_10_1","first-page":"564","volume-title":"Principles and practice of endocrinology and metabolism","author":"Silverberg JS","year":"2001"},{"key":"e_1_2_4_11_1","first-page":"1696","volume-title":"Principles and practice of endocrinology and metabolism","author":"Sizemore GW","year":"2001"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19990115)82:2<187::AID-AJMG17>3.0.CO;2-2"}],"container-title":["American Journal of Medical Genetics Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.a.20361","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.a.20361","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T23:52:21Z","timestamp":1697673141000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.a.20361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,6,16]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,1,15]]}},"alternative-id":["10.1002\/ajmg.a.20361"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.a.20361","archive":["Portico"],"relation":{},"ISSN":["1552-4825","1552-4833"],"issn-type":[{"value":"1552-4825","type":"print"},{"value":"1552-4833","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,6,16]]}}}