{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T17:10:08Z","timestamp":1697649008222},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2003,6,30]],"date-time":"2003-06-30T00:00:00Z","timestamp":1056931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2003,8,30]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this study we describe two patients with congenital absence of alpha\u2010fetoprotein (AFP). The pathological examination results, including an immunohistochemical stain, which define qualitatively the levels of AFP detected by the biochemical studies and the comparative genomic hybridization (CGH) are enclosed. A description of the suggested functions of AFP and the means of its production are set forth. An explanation is suggested for the lack of symptoms in a newborn with undetectable levels of AFP and the mechanism by which this condition might occur. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.a.20397","type":"journal-article","created":{"date-parts":[[2003,8,5]],"date-time":"2003-08-05T15:49:12Z","timestamp":1060098552000},"page":"113-117","source":"Crossref","is-referenced-by-count":4,"title":["Congenital deficiency of alpha\u2010fetoprotein and associated chromosomal abnormality in the placenta"],"prefix":"10.1002","volume":"121A","author":[{"given":"Reuven","family":"Sharony","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aliza","family":"Amiel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nitsan","family":"Bouaron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debora","family":"Kidron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dganit","family":"Itzhaky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moshe","family":"Fejgin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,6,30]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00379a020"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1975.tb25397.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(11)91441-0"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2432657"},{"key":"e_1_2_5_6_1","first-page":"565","article-title":"Linkage of the evolutionarily\u2010related serum albumin and AFP genes within q11\u201022 of human chromosome 4","volume":"35","author":"Harper ME","year":"1983","journal-title":"Am J Hum Genet"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870100403"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9926(199905)59:5<325::AID-TERA3>3.0.CO;2-N"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/2.4.379"},{"key":"e_1_2_5_10_1","first-page":"347","article-title":"The rate of molecular evolution of AFP approaches that of pseudogenes","volume":"2","author":"Minghetti PP","year":"1985","journal-title":"Mol Biol Evol"},{"key":"e_1_2_5_11_1","first-page":"5","volume-title":"AFP and congenital disorders","author":"Mizejewski GJ","year":"1985"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198301000-00009"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.11.12.6041"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/260804a0"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199709)17:9<884::AID-PD163>3.0.CO;2-N"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.17.5254"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2436297"},{"key":"e_1_2_5_18_1","doi-asserted-by":"crossref","first-page":"4812","DOI":"10.1016\/S0021-9258(18)61269-4","article-title":"Cell\u2010specific enhancer activity in a far upstream region of the human AFP gene","volume":"262","author":"Watanabe K","year":"1987","journal-title":"J Biol Chem"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1995.9967"}],"container-title":["American Journal of Medical Genetics Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.a.20397","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.a.20397","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T16:54:28Z","timestamp":1697648068000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.a.20397"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,6,30]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2003,8,30]]}},"alternative-id":["10.1002\/ajmg.a.20397"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.a.20397","archive":["Portico"],"relation":{},"ISSN":["1552-4825","1552-4833"],"issn-type":[{"value":"1552-4825","type":"print"},{"value":"1552-4833","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,6,30]]}}}