{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T05:10:51Z","timestamp":1781241051954,"version":"3.54.1"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,8,18]],"date-time":"2003-08-18T00:00:00Z","timestamp":1061164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2003,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This article describes four patients with non\u2010ossifying fibromas (NOFs) and multiple caf\u00e9\u2010au\u2010lait spots. Two of the patients were diagnosed with NOFs when they presented with a femur fracture. The other two patients were diagnosed with NOFs because of complaints of leg problems. In addition, axillary freckles and Lisch nodules were present in all four patients and multiple cutaneous neurofibromas in two patients. These four patients fulfilled the diagnostic criteria for neurofibromatosis type 1 (NF1) and also have been diagnosed with Jaffe\u2013Campanacci syndrome. We propose that Jaffe\u2013Campanacci syndrome is a manifestation of NF1 and suggest that patients with NF1 should have more rigorous radiographic screening of the long bones during early adolescence or adulthood to determine the presence or absence of NOFs. Appropriate intervention (exercise restriction, bracing, and\/or surgery) might decrease the long\u2010term disability associated with Jaffe\u2013Campanacci syndrome. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.a.20490","type":"journal-article","created":{"date-parts":[[2003,10,7]],"date-time":"2003-10-07T04:03:09Z","timestamp":1065499389000},"page":"60-63","source":"Crossref","is-referenced-by-count":30,"title":["Is Jaffe\u2013Campanacci syndrome just a manifestation of neurofibromatosis type 1?"],"prefix":"10.1002","volume":"123A","author":[{"given":"Randall S.","family":"Colby","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Saul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,8,18]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-54-641-416"},{"key":"e_1_2_4_3_1","doi-asserted-by":"crossref","first-page":"299","DOI":"10.2106\/00004623-198870020-00022","article-title":"Multiple non\u2010ossifying fibromas","volume":"70","author":"Blau RA","year":"1988","journal-title":"J Bone Joint Surg"},{"key":"e_1_2_4_4_1","first-page":"108","article-title":"Jaffe\u2013Campanacci syndrome. Report of a case","volume":"14","author":"Boivin C","year":"1994","journal-title":"Ann Pathol"},{"key":"e_1_2_4_5_1","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1302\/0301-620X.65B5.6643569","article-title":"Multiple non\u2010ossifying fibromata with extraskeletal anomalies: A new syndrome?","volume":"65","author":"Campanacci M","year":"1983","journal-title":"J Bone Joint Surg"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1048583"},{"key":"e_1_2_4_7_1","first-page":"369","article-title":"Multiple and large non\u2010ossifying fibromas in children with neurofibromatosis","volume":"29","author":"Faur\u00e9 C","year":"1986","journal-title":"Ann Radiol"},{"key":"e_1_2_4_8_1","first-page":"2407","article-title":"Von Recklinghausen's neurofibromatosis with nonosteogenic fibroma","volume":"75","author":"Goodnough CP","year":"1975","journal-title":"NY State J Med"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00361432"},{"key":"e_1_2_4_10_1","doi-asserted-by":"crossref","first-page":"634","DOI":"10.2106\/00004623-200204000-00022","article-title":"Jaffe\u2013Campanacci syndrome","volume":"84","author":"Hau MA","year":"2002","journal-title":"J Bone Joint Surg"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1148\/51.5.647"},{"key":"e_1_2_4_12_1","first-page":"449","volume-title":"Tumors and tumorous conditions of the bones and joints","author":"Jaffe HL","year":"1958"},{"key":"e_1_2_4_13_1","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1097\/00019605-199410000-00008","article-title":"Jaffe\u2013Campanacci syndrome: Case report and review of literature","volume":"3","author":"Kotzot D","year":"1994","journal-title":"Clin Dysmorphol"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.133.6.1135"},{"key":"e_1_2_4_15_1","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1097\/00003086-198208000-00036","article-title":". 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