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Replication banding studies on Epstein\u2013Barr virus transformed peripheral blood lymphocytes revealed non\u2010random X chromosome inactivation with predominant inactivation of the derivative X chromosome. Using chromosomal fluorescence <jats:italic>in situ<\/jats:italic> hybridization (FISH), we located the breakpoints to a 30 kb region on the short arm of the X chromosome band p11.3 and to a 160 kb region defined by BAC RP11\u201089K11 on the long arm of chromosome 15. Our data suggest that the disruption\/disturbance of plant homeo domain (PHD) zinc finger gene <jats:italic>KIAA0215<\/jats:italic> or of another gene (<jats:italic>RGN<\/jats:italic>, <jats:italic>RNU12<\/jats:italic>, <jats:italic>P17.3<\/jats:italic>, or <jats:italic>RBM10<\/jats:italic>) in the breakpoint region on the X chromosome is not well tolerated and leads to the selection of cells with an active non\u2010rearranged X chromosome. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.a.20584","type":"journal-article","created":{"date-parts":[[2004,3,26]],"date-time":"2004-03-26T08:07:05Z","timestamp":1080288425000},"page":"229-236","source":"Crossref","is-referenced-by-count":10,"title":["Molecular cytogenetic analysis of a <i>de novo<\/i> balanced X;autosome translocation: Evidence for predominant inactivation of the derivative X chromosome in a girl with multiple malformations"],"prefix":"10.1002","volume":"126A","author":[{"given":"B.","family":"Gl\u00e4ser","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Shirneshan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Bink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Wirth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Kehrer\u2010Sawatzki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Bartz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Zoll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan 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