{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T14:08:09Z","timestamp":1770991689346,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,12,17]],"date-time":"2003-12-17T00:00:00Z","timestamp":1071619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Tourette Syndrome Association"},{"name":"Mexican National Council for Science and Technology (CONACyT) (to A.D.A.)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2004,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tourette syndrome (TS) is a complex neuropychiatric disorder with a strong genetic basis. Although no specific susceptibility genes have been identified for TS, cytogenetic studies in selected cases suggest the existence of a predisposing gene located in the 7q31 chromosomal region. In order to test the hypothesis of a possible relationship between this region and TS at the population level, we undertook a family based association study in a sample of French Canadian patients from Quebec. For this purpose, markers D7S522, D7S523, and D7S1516 were tested using the extended transmission disequilibrium test (e\u2010TDT). Marker D7S522 showed a biased transmission of alleles from heterozygote parents to their TS offsprings (allele\u2010wise TDT \u03c7<jats:sup>2<\/jats:sup>\u2009=\u200912.61, 4 df,<jats:italic>P<\/jats:italic>\u2009=\u20090.013, genotype\u2010wise TDT \u03c7<jats:sup>2<\/jats:sup>\u2009=\u200915.49, 7 df,<jats:italic>P<\/jats:italic>\u2009=\u20090.030). When the analysis was restricted to patients without ADHD or OCD comorbidity, similar results were observed both allele and genotype\u2010wise (\u03c7<jats:sup>2<\/jats:sup>\u2009=\u200910.68, 4 df,<jats:italic>P<\/jats:italic>\u2009=\u20090.03 and \u03c7<jats:sup>2<\/jats:sup>\u2009=\u200912.55, 5 df,<jats:italic>P<\/jats:italic>\u2009=\u20090.028, respectively). In addition, marker D7S523 was also associated (allele\u2010wise TDT \u03c7<jats:sup>2<\/jats:sup>\u2009=\u200918.37, 7 df,<jats:italic>P<\/jats:italic>\u2009=\u20090.01 and genotype\u2010wise TDT \u03c7<jats:sup>2<\/jats:sup>\u2009=\u200946.26, 17 df,<jats:italic>P<\/jats:italic>\u2009=\u20090.00016), and showed a tendency for association in the comorbidity\u2010free subgroup (genotype\u2010wise TDT \u03c7<jats:sup>2<\/jats:sup>\u2009=\u200918.7, 10 df,<jats:italic>P<\/jats:italic>\u2009=\u20090.044). Finally, marker D7S1516, contained in the inner mitochondrial membrane peptidase 2 like (<jats:italic>IMMP2L<\/jats:italic>) gene, also showed a tendency for association (genotype\u2010wise TDT \u03c7<jats:sup>2<\/jats:sup>\u2009=\u200932.87, 21 df,<jats:italic>P<\/jats:italic>\u2009=\u20090.048). These results may reflect the proximity of markers D7S522, D7S523, and possibly D7S1516 to a gene or regulatory region relevant to TS predisposition. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.a.20631","type":"journal-article","created":{"date-parts":[[2004,4,15]],"date-time":"2004-04-15T22:04:50Z","timestamp":1082066690000},"page":"17-20","source":"Crossref","is-referenced-by-count":31,"title":["Association between 7q31 markers and tourette syndrome"],"prefix":"10.1002","volume":"127A","author":[{"given":"Adriana","family":"D\u00edaz\u2010Anzald\u00faa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ridha","family":"Joober","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Baptiste","family":"Rivi\u00e8re","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves","family":"Dion","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Lesp\u00e9rance","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvain","family":"Chouinard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francois","family":"Richer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy Armand","family":"Rouleau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Montreal Tourette Syndrome Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,12,17]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association","year":"1994"},{"key":"e_1_2_7_3_1","first-page":"999","article-title":"Tourette syndrome in a pedigree with a 7:18 translocation: Identification of a YAC spanning the translocation breakpoint at 18q22.3","volume":"59","author":"Boghosian\u2010Sell L","year":"1996","journal-title":"Am J Hum 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