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Among 5,260 infants with multiple malformations collected from 4 large registers of congenital malformations, we identified 312 probable OAV cases. With the same technique, we have earlier defined epidemiological delineations of three other well\u2010known non\u2010random associations of congenital malformations (CHARGE, VATER, and OEIS). We found convincing relationships between OAV and VATER or CHARGE but none between OAV and OEIS or between the three malformation complexes CHARGE, VATER, and OEIS. An association between two conditions indicates similarities in pathogenesis or in etiology. We suggest that the connection between OAV and CHARGE could be related to a common pathogenetic mechanism: disturbed neural crest development. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.a.20643","type":"journal-article","created":{"date-parts":[[2004,4,15]],"date-time":"2004-04-15T22:03:41Z","timestamp":1082066621000},"page":"26-34","source":"Crossref","is-referenced-by-count":43,"title":["Relation between oculo\u2010auriculo\u2010vertebral (OAV) dysplasia and three other non\u2010random associations of malformations (VATER, CHARGE, and OEIS)"],"prefix":"10.1002","volume":"127A","author":[{"given":"Karin","family":"K\u00e4ll\u00e9n","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Robert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo E.","family":"Castilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierpaolo","family":"Mastroiacovo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bengt","family":"K\u00e4ll\u00e9n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,12,17]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9926(199710)56:4<244::AID-TERA3>3.0.CO;2-Z"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.3928\/0191-3913-19841101-03"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.20167"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1996.tb02397.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/000992289803700302"},{"key":"e_1_2_5_7_1","first-page":"276","article-title":"Oculoauriculovertebral spectrum: An update critique","volume":"26","author":"Cohen MM","year":"1989","journal-title":"Cleft Palate J"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320470116"},{"key":"e_1_2_5_9_1","first-page":"167","article-title":"Craniovertebral malformations in hemifacial microsomia","volume":"1","author":"Figueroa AA","year":"1985","journal-title":"J Craniofac Genet Dev Biol Suppl"},{"key":"e_1_2_5_10_1","first-page":"243","article-title":"Associations malformatives de l'oeil et de l'oreille. 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