{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T20:46:56Z","timestamp":1760906816505},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,4,21]],"date-time":"2004-04-21T00:00:00Z","timestamp":1082505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2004,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Two small supernumerary mosaic marker chromosomes (SMC) were identified by conventional cytogenetics, one prenatally, the other postnatally. Fluorescence in situ hybridization (FISH) techniques, including 24\u2010color FISH, were applied to identify both SMCs and better characterize their constitution. Patient 1: a 29 year\u2010old man, whose wife had a spontaneous abortion, was found to have a small ring of the pericentromeric region of chromosome 8 (47,XY,+r(8)(p11q11)\/46,XY). Patient 2: a 37 year\u2010old woman had amniocentesis. The fetus was found to have a SMC; its presence was confirmed postnatally. Several FISH techniques (24\u2010color, whole chromosome paints, centromeres, telomeres, band 8p22) led to the identification of a small analphoid marker. The marker was an inversion\u2013duplication for part of the short arm of chromosome 8 (47,XY,+inv dup (8)(p23pter)\/46,XY). The 24\u2010color FISH allowed us to conclude that both markers originated exclusively from chromosome 8. However, the structure and content of the markers were elucidated using other molecular cytogenetic techniques, showing their complementarity. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.a.30077","type":"journal-article","created":{"date-parts":[[2004,4,21]],"date-time":"2004-04-21T21:01:38Z","timestamp":1082581298000},"page":"33-38","source":"Crossref","is-referenced-by-count":8,"title":["Molecular cytogenetic characterization of two small chromosome 8 derived supernumerary mosaic markers"],"prefix":"10.1002","volume":"128A","author":[{"given":"A.","family":"Herry","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Morel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.\u2010J.","family":"Le 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