{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T08:35:18Z","timestamp":1791016518290,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,8,24]],"date-time":"2004-08-24T00:00:00Z","timestamp":1093305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2004,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>It remains uncertain whether members of hereditary breast and ovarian cancer (HBOC) families experience psychological distress with genetic testing and whether pre\u2010test counseling can have a moderating effect on client well\u2010being. One purpose of this study was to assess change in psychological well\u2010being from baseline to 6\u20139 months follow\u2010up and the effect of a problem\u2010solving training (PST) intervention on psychological well\u2010being. Two hundred and twelve members of 13 HBOC families were offered<jats:italic>BRCA1\/2<\/jats:italic>testing for a previously identified family mutation. Participants received education and were randomized to one of two counseling interventions; PST or client\u2010centered counseling. Psychological well\u2010being was assessed at baseline and again at 6\u20139 months following the receipt of test results, or at the equivalent time for those participants who chose not to undergo testing. Well\u2010being was assessed using measures of depressive symptoms (CESD), intrusive thoughts (IES), cancer worries, and self\u2010esteem. Comparisons were made between those who chose testing and those who did not as well as between those who received positive and negative test results. One hundred eighty one participants elected to undergo genetic testing (85%) and 47 of these (26%) were identified as<jats:italic>BRCA1\/2<\/jats:italic>mutation carriers. Breast and ovarian cancer worries decreased significantly (<jats:italic>p<\/jats:italic>\u2009=\u20090.007 and 0.008, respectively) in those who tested negative while there was no appreciable change in psychological well\u2010being from baseline to follow\u2010up in either those who tested positive or in non\u2010testers. Among all participants, particularly testers, those randomized to PST had a greater reduction in depressive symptoms than those randomized to client\u2010centered counseling (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05 and<jats:italic>p<\/jats:italic>\u2009=\u20090.02, respectively). Regardless of the decision to test, individuals with a personal history of cancer (n\u2009=\u200922) were more likely to have an increase in breast cancer worries compared to those who had never been diagnosed with cancer (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Results suggest that a problem\u2010solving counseling intervention may help to enhance psychological well\u2010being following testing and that a personal history of cancer may increase psychological distress associated with genetic testing. Published 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.a.30265","type":"journal-article","created":{"date-parts":[[2004,8,24]],"date-time":"2004-08-24T22:01:58Z","timestamp":1093384918000},"page":"221-227","source":"Crossref","is-referenced-by-count":39,"title":["<i>BRCA1\/2<\/i>testing in hereditary breast and ovarian cancer families: Effectiveness of problem\u2010solving training as a counseling intervention"],"prefix":"10.1002","volume":"130A","author":[{"given":"Aideen","family":"McInerney\u2010Leo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara Bowles","family":"Biesecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald W.","family":"Hadley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald G.","family":"Kase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Therese R.","family":"Giambarresi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caryn","family":"Lerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffery P.","family":"Struewing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,8,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.1014"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1611(199905\/06)8:3<220::AID-PON370>3.0.CO;2-C"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600030"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/88.13.872"},{"key":"e_1_2_6_6_1","volume-title":"Measures for clinical practice: A sourcebook","author":"Corcoran K","year":"1994"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1006\/pmed.1993.1023"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1037\/0278-6133.16.1.63"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","DOI":"10.1891\/0889-8391.2.4.283a","volume-title":"Problem\u2010solving therapy: A social competence approach to clinical intervention","author":"D'Zurilla TJ","year":"1988"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.10.2135"},{"key":"e_1_2_6_11_1","first-page":"265","article-title":"Breast and ovarian cancer incidence in BRCA1\u2010mutation carriers. 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