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Here we illustrate that genomic arrays can also provide novel clues regarding the structural basis of chromosome rearrangement, including instability and mechanisms of formation of ring chromosomes. We also showed that array results might impact the recurrence risks for relatives of affected individuals. Our data indicate that chromosome rearrangements frequently involve more breaks than current cytogenetic models assume. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.a.30378","type":"journal-article","created":{"date-parts":[[2004,11,23]],"date-time":"2004-11-23T01:27:59Z","timestamp":1101173279000},"page":"36-40","source":"Crossref","is-referenced-by-count":43,"title":["Insights from genomic microarrays into structural chromosome rearrangements"],"prefix":"10.1002","volume":"132A","author":[{"given":"Jeroen","family":"Knijnenburg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K\u00e1roly","family":"Szuhai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Giltay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lia","family":"Molenaar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willem","family":"Sloos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Poot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans J.","family":"Tanke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Rosenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,11,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg261"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/75985"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.20163"},{"key":"e_1_2_6_5_1","first-page":"769","article-title":"Chromosomal origin of small ring marker chromosomes in man: Characterization by molecular genetics","volume":"48","author":"Callen DF","year":"1991","journal-title":"Am J Hum Genet"},{"key":"e_1_2_6_6_1","first-page":"769","article-title":"Chromosomal origin of small ring marker chromosomes in man: Characterization by molecular genetics [published erratum appears in Am J Hum Genet 1991 Aug;49(2):503]","volume":"48","author":"Callen DF","year":"1991","journal-title":"American Journal of Human Genetics"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.10153"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.10155"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59259-643-0_9"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1359641"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.82802"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00216140"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/2524"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5200604"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2264(199712)20:4<399::AID-GCC12>3.0.CO;2-I"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.20184"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000074166"},{"key":"e_1_2_6_18_1","first-page":"2872","article-title":"Array\u2010based comparative genomic hybridization for genome\u2010wide screening of DNA copy number in bladder tumors","volume":"63","author":"Veltman JA","year":"2003","journal-title":"Cancer Research"}],"container-title":["American Journal of Medical Genetics Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.a.30378","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.a.30378","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T19:51:24Z","timestamp":1697658684000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.a.30378"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11,22]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,1]]}},"alternative-id":["10.1002\/ajmg.a.30378"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.a.30378","archive":["Portico"],"relation":{},"ISSN":["1552-4825","1552-4833"],"issn-type":[{"value":"1552-4825","type":"print"},{"value":"1552-4833","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,11,22]]}}}