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He was suboptimally controlled with phosphate and calcitriol treatment and sustained numerous insufficiency fractures ipsilateral to the linear sebaceous nevus. Fibroblast growth factor\u201023 (FGF\u201023), the phosphaturic peptide, was elevated in the plasma. Treamtent with the somatostatin agonist, octreotide, and excision of the nevus were followed by normalization of FGF\u201023 and clinical improvement. The patient also had hyperimmunoglobulinemia E, which responded to octreotide and surgery. We speculate that in some patients with LNSS there may be more than one mediator of hypophosphatemia and that FGF\u201023 is the mediator of hyperphosphaturia in this and other hypophosphatemic syndromes. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.a.30599","type":"journal-article","created":{"date-parts":[[2005,3,2]],"date-time":"2005-03-02T10:48:37Z","timestamp":1109760517000},"page":"233-236","source":"Crossref","is-referenced-by-count":76,"title":["Elevated fibroblast growth factor\u201023 in hypophosphatemic linear nevus sebaceous syndrome"],"prefix":"10.1002","volume":"134A","author":[{"given":"William H.","family":"Hoffman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald W.","family":"Jueppner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry R.","family":"DeYoung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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